Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model
Abstract Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-03-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/clt2.12128 |
| _version_ | 1818261766594887680 |
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| author | Bernardo Sousa‐Pinto Luís Filipe Azevedo Ana Sá‐Sousa Rafael José Vieira Rita Amaral Ludger Klimek Wienczyslawa Czarlewski Josep M. Anto Anna Bedbrook Violeta Kvedariene Maria Teresa Ventura Ignacio J. Ansotegui Karl‐Christian Bergmann Luisa Brussino G. Walter Canonica Victoria Cardona Pedro Carreiro‐Martins Thomas Casale Lorenzo Cecchi Tomás Chivato Derek K. Chu Cemal Cingi Elisio M. Costa Alvaro A. Cruz Giulia De Feo Philippe Devillier Wytske J. Fokkens Mina Gaga Bilun Gemicioğlu Tari Haahtela Juan Carlos Ivancevich Zhanat Ispayeva Marek Jutel Piotr Kuna Igor Kaidashev Helga Kraxner Désirée E. Larenas‐Linnemann Daniel Laune Brian Lipworth Renaud Louis Michaël Makris Riccardo Monti Mario Morais‐Almeida Ralph Mösges Joaquim Mullol Mikaëla Odemyr Yoshitaka Okamoto Nikolaos G. Papadopoulos Vincenzo Patella Nhân Pham‐Thi Frederico S. Regateiro Sietze Reitsma Philip W. Rouadi Boleslaw Samolinski Milan Sova Ana Todo‐Bom Luis Taborda‐Barata Peter Valentin Tomazic Sanna Toppila‐Salmi Joaquin Sastre Ioanna Tsiligianni Arunas Valiulis Dana Wallace Susan Waserman Arzu Yorgancioglu Mihaela Zidarn Torsten Zuberbier João Almeida Fonseca Jean Bousquet Oliver Pfaar |
| author_facet | Bernardo Sousa‐Pinto Luís Filipe Azevedo Ana Sá‐Sousa Rafael José Vieira Rita Amaral Ludger Klimek Wienczyslawa Czarlewski Josep M. Anto Anna Bedbrook Violeta Kvedariene Maria Teresa Ventura Ignacio J. Ansotegui Karl‐Christian Bergmann Luisa Brussino G. Walter Canonica Victoria Cardona Pedro Carreiro‐Martins Thomas Casale Lorenzo Cecchi Tomás Chivato Derek K. Chu Cemal Cingi Elisio M. Costa Alvaro A. Cruz Giulia De Feo Philippe Devillier Wytske J. Fokkens Mina Gaga Bilun Gemicioğlu Tari Haahtela Juan Carlos Ivancevich Zhanat Ispayeva Marek Jutel Piotr Kuna Igor Kaidashev Helga Kraxner Désirée E. Larenas‐Linnemann Daniel Laune Brian Lipworth Renaud Louis Michaël Makris Riccardo Monti Mario Morais‐Almeida Ralph Mösges Joaquim Mullol Mikaëla Odemyr Yoshitaka Okamoto Nikolaos G. Papadopoulos Vincenzo Patella Nhân Pham‐Thi Frederico S. Regateiro Sietze Reitsma Philip W. Rouadi Boleslaw Samolinski Milan Sova Ana Todo‐Bom Luis Taborda‐Barata Peter Valentin Tomazic Sanna Toppila‐Salmi Joaquin Sastre Ioanna Tsiligianni Arunas Valiulis Dana Wallace Susan Waserman Arzu Yorgancioglu Mihaela Zidarn Torsten Zuberbier João Almeida Fonseca Jean Bousquet Oliver Pfaar |
| author_sort | Bernardo Sousa‐Pinto |
| collection | DOAJ |
| description | Abstract Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK‐air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods We assessed the MASK‐air® data of European users with self‐reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom‐medication score (CSMS). We applied Bayesian mixed‐effects models, with clustering by patient, country and pollen season. Results We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT‐tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT‐tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion In patients with grass pollen allergy, SLIT‐tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally‐harmonised standards for performing and reporting real‐world data in AIT are needed to better understand its ‘real‐world’ effectiveness. |
| first_indexed | 2024-12-12T18:52:27Z |
| format | Article |
| id | doaj.art-9ce72786cd364a1790e07c62806231bf |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-12T18:52:27Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-9ce72786cd364a1790e07c62806231bf2022-12-22T00:15:20ZengWileyClinical and Translational Allergy2045-70222022-03-01123n/an/a10.1002/clt2.12128Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects modelBernardo Sousa‐Pinto0Luís Filipe Azevedo1Ana Sá‐Sousa2Rafael José Vieira3Rita Amaral4Ludger Klimek5Wienczyslawa Czarlewski6Josep M. Anto7Anna Bedbrook8Violeta Kvedariene9Maria Teresa Ventura10Ignacio J. Ansotegui11Karl‐Christian Bergmann12Luisa Brussino13G. Walter Canonica14Victoria Cardona15Pedro Carreiro‐Martins16Thomas Casale17Lorenzo Cecchi18Tomás Chivato19Derek K. Chu20Cemal Cingi21Elisio M. Costa22Alvaro A. Cruz23Giulia De Feo24Philippe Devillier25Wytske J. Fokkens26Mina Gaga27Bilun Gemicioğlu28Tari Haahtela29Juan Carlos Ivancevich30Zhanat Ispayeva31Marek Jutel32Piotr Kuna33Igor Kaidashev34Helga Kraxner35Désirée E. Larenas‐Linnemann36Daniel Laune37Brian Lipworth38Renaud Louis39Michaël Makris40Riccardo Monti41Mario Morais‐Almeida42Ralph Mösges43Joaquim Mullol44Mikaëla Odemyr45Yoshitaka Okamoto46Nikolaos G. Papadopoulos47Vincenzo Patella48Nhân Pham‐Thi49Frederico S. Regateiro50Sietze Reitsma51Philip W. Rouadi52Boleslaw Samolinski53Milan Sova54Ana Todo‐Bom55Luis Taborda‐Barata56Peter Valentin Tomazic57Sanna Toppila‐Salmi58Joaquin Sastre59Ioanna Tsiligianni60Arunas Valiulis61Dana Wallace62Susan Waserman63Arzu Yorgancioglu64Mihaela Zidarn65Torsten Zuberbier66João Almeida Fonseca67Jean Bousquet68Oliver Pfaar69MEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalDepartment of Otolaryngology, Head and Neck Surgery Universitätsmedizin Mainz Mainz GermanyMedical Consulting Czarlewski Levallois FranceISGlobal, Barcelona Institute for Global Health Barcelona SpainMASK‐air Montpellier FranceInstitute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University Vilnius LithuaniaUniversity of Bari Medical School Unit of Geriatric Immunoallergology Bari ItalyDepartment of Allergy and Immunology Hospital Quirónsalud Bizkaia Bilbao SpainInstitute of Allergology Charité—Universitätsmedizin Berlin Berlin GermanyDepartment of Medical Sciences Allergy and Clinical Immunology Unit University of Torino & Mauriziano Hospital Torino ItalyDepartment of Biomedical Sciences Humanitas University Pieve Emanuele ItalyAllergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network Barcelona SpainServiço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central Lisbon PortugalDivision of Allergy/immunology University of South Florida Tampa Florida USASOS Allergology and Clinical Immunology, USL Toscana Centro Prato ItalySchool of Medicine University CEU San Pablo Madrid SpainDepartment of Medicine and Health Research Methods, Evidence & Impact, McMaster University Hamilton Ontario CanadaEskisehir Osmangazi University Medical Faculty ENT Department Eskisehir TurkeyUCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing) Porto PortugalFundaçao ProAR, Federal University of Bahia Salvador Bahia BrazilDepartment of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno Salerno ItalyVIM Suresnes, UMR_0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris‐Saclay Suresnes FranceDepartment of Otorhinolaryngology Amsterdam University Medical Centres, location AMC Amsterdam The NetherlandsERS President 2017−2018, Athens Chest Hospital, 7th Respiratory Medicine Department and Asthma Center Athens GreeceDepartment of Pulmonary Diseases Istanbul University‐Cerrahpasa Cerrahpasa Faculty of Medicine Istanbul TurkeySkin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki FinlandServicio de Alergia e Immunologia, Clinica Santa Isabel Buenos Aires ArgentinaDepartment of Allergology and Clinical Immunology of the Kazakh National Medical University Almaty KazakhstanDepartment of Clinical Immunology Wrocław Medical University Wroclaw PolandDivision of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz Lodz PolandPoltava State Medical University Poltava UkraineDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University Budapest HungaryCenter of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City MexicoKYomed INNOV Montpellier FranceScottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee Dundee UKDepartment of Pulmonary Medicine CHU Sart‐Tilman Liege BelgiumAllergy Unit ‘D Kalogeromitros’, 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, ‘Attikon’ University Hospital Chaidari GreeceDepartment of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A Gemelli IRCCS Università Cattolica del Sacro Cuore Rome ItalyAllergy Center CUF Descobertas Hospital Lisbon PortugalClinCompetence Cologne GmbH Cologne GermanyRhinology Unit & Smell Clinic, ENT Department, Hospital Clínic Barcelona SpainEFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels BelgiumDepartment of Otorhinolaryngology Chiba University Hospital Chiba JapanAllergy Department, 2nd Pediatric Clinic, University of Athens Athens GreeceDivision of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, ‘Santa Maria della Speranza’ Hospital Salerno ItalyEcole Polytechnique Palaiseau, IRBA (Institut de Recherche bio‐Médicale des Armées) Bretigny FranceMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalDepartment of Otorhinolaryngology Amsterdam University Medical Centres, location AMC Amsterdam The NetherlandsDepartment of Otolaryngology‐Head and Neck Surgery, Eye and Ear University Hospital Beirut LebanonDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw Warsaw PolandDepartment of Pulmonary Medicine and Tuberculosis University Hospital Brno Liskovec Czech RepublicMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalFaculty of Health Sciences University of Beira Interior Covilhã PortugalDepartment of General ORL, H&NS, Medical University of Graz, ENT‐University Hospital Graz Graz AustriaSkin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki FinlandFundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid Madrid SpainHealth Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete Rethymno GreeceInstitute of Clinical Medicine and Institute of Health Sciences Medical Faculty of Vilnius University Vilnius LithuaniaNova Southeastern University Fort Lauderdale Florida USADepartment of Medicine, Clinical Immunology and Allergy, McMaster University Hamilton Ontario CanadaDepartment of Pulmonology Celal Bayar University Manisa TurkeyUniversity Clinic of Respiratory and Allergic Diseases Golnik SloveniaInstitute of Allergology Charité—Universitätsmedizin Berlin Berlin GermanyMEDCIDS—Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto Porto PortugalInstitute of Allergology Charité—Universitätsmedizin Berlin Berlin GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy University Hospital Marburg, Philipps‐Universität Marburg Marburg GermanyAbstract Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK‐air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods We assessed the MASK‐air® data of European users with self‐reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom‐medication score (CSMS). We applied Bayesian mixed‐effects models, with clustering by patient, country and pollen season. Results We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT‐tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT‐tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion In patients with grass pollen allergy, SLIT‐tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally‐harmonised standards for performing and reporting real‐world data in AIT are needed to better understand its ‘real‐world’ effectiveness.https://doi.org/10.1002/clt2.12128allergic rhinitisimmunotherapymobile healthpatient‐reported outcomesreal‐life data analysis |
| spellingShingle | Bernardo Sousa‐Pinto Luís Filipe Azevedo Ana Sá‐Sousa Rafael José Vieira Rita Amaral Ludger Klimek Wienczyslawa Czarlewski Josep M. Anto Anna Bedbrook Violeta Kvedariene Maria Teresa Ventura Ignacio J. Ansotegui Karl‐Christian Bergmann Luisa Brussino G. Walter Canonica Victoria Cardona Pedro Carreiro‐Martins Thomas Casale Lorenzo Cecchi Tomás Chivato Derek K. Chu Cemal Cingi Elisio M. Costa Alvaro A. Cruz Giulia De Feo Philippe Devillier Wytske J. Fokkens Mina Gaga Bilun Gemicioğlu Tari Haahtela Juan Carlos Ivancevich Zhanat Ispayeva Marek Jutel Piotr Kuna Igor Kaidashev Helga Kraxner Désirée E. Larenas‐Linnemann Daniel Laune Brian Lipworth Renaud Louis Michaël Makris Riccardo Monti Mario Morais‐Almeida Ralph Mösges Joaquim Mullol Mikaëla Odemyr Yoshitaka Okamoto Nikolaos G. Papadopoulos Vincenzo Patella Nhân Pham‐Thi Frederico S. Regateiro Sietze Reitsma Philip W. Rouadi Boleslaw Samolinski Milan Sova Ana Todo‐Bom Luis Taborda‐Barata Peter Valentin Tomazic Sanna Toppila‐Salmi Joaquin Sastre Ioanna Tsiligianni Arunas Valiulis Dana Wallace Susan Waserman Arzu Yorgancioglu Mihaela Zidarn Torsten Zuberbier João Almeida Fonseca Jean Bousquet Oliver Pfaar Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model Clinical and Translational Allergy allergic rhinitis immunotherapy mobile health patient‐reported outcomes real‐life data analysis |
| title | Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model |
| title_full | Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model |
| title_fullStr | Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model |
| title_full_unstemmed | Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model |
| title_short | Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model |
| title_sort | allergen immunotherapy in mask air users in real life results of a bayesian mixed effects model |
| topic | allergic rhinitis immunotherapy mobile health patient‐reported outcomes real‐life data analysis |
| url | https://doi.org/10.1002/clt2.12128 |
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