Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects

The advent of nanotechnology has had a revolutionary impact on many aspects of 21st century life. Nanotechnology has provided an opportunity to explore new avenues that conventional technologies have been unable to make an impact on for diagnosis, prevention, and therapy of different diseases, and o...

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Main Authors: Hasan Mukhtar, Dhruba J. Bharali, Imtiaz A. Siddiqui, Vaqar M. Adhami, Jean Christopher Chamcheu, Abdullah M. Aldahmash, Shaker A. Mousa
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/3/4/4024/
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author Hasan Mukhtar
Dhruba J. Bharali
Imtiaz A. Siddiqui
Vaqar M. Adhami
Jean Christopher Chamcheu
Abdullah M. Aldahmash
Shaker A. Mousa
author_facet Hasan Mukhtar
Dhruba J. Bharali
Imtiaz A. Siddiqui
Vaqar M. Adhami
Jean Christopher Chamcheu
Abdullah M. Aldahmash
Shaker A. Mousa
author_sort Hasan Mukhtar
collection DOAJ
description The advent of nanotechnology has had a revolutionary impact on many aspects of 21st century life. Nanotechnology has provided an opportunity to explore new avenues that conventional technologies have been unable to make an impact on for diagnosis, prevention, and therapy of different diseases, and of cancer in particular. Entities in nanometer sizes are excellent platforms to incorporate various drugs or active materials that can be delivered effectively to the desired action site without compromising the activity of the incorporated drug or material. In particular, nanotechnology entities can be used to deliver conventional natural products that have poor solubility or a short half life. Conventional natural products used with entities in nanometer sizes enable us to solve many of the inherent problems (stability, solubility, toxicity) associated with natural products, and also provide a platform for targeted delivery to tumor sites. We recently introduced the novel concept of using nanotechnology for enhancing the outcome of chemoprevention, which we called ‘nanochemoprevention’. This idea was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the applications of nanotechnology for cancer prevention and therapy using natural products.
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spelling doaj.art-9ce98a95b4154b0093afe59ab97f70e12023-08-02T06:44:03ZengMDPI AGCancers2072-66942011-10-01344024404510.3390/cancers3044024Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future ProspectsHasan MukhtarDhruba J. BharaliImtiaz A. SiddiquiVaqar M. AdhamiJean Christopher ChamcheuAbdullah M. AldahmashShaker A. MousaThe advent of nanotechnology has had a revolutionary impact on many aspects of 21st century life. Nanotechnology has provided an opportunity to explore new avenues that conventional technologies have been unable to make an impact on for diagnosis, prevention, and therapy of different diseases, and of cancer in particular. Entities in nanometer sizes are excellent platforms to incorporate various drugs or active materials that can be delivered effectively to the desired action site without compromising the activity of the incorporated drug or material. In particular, nanotechnology entities can be used to deliver conventional natural products that have poor solubility or a short half life. Conventional natural products used with entities in nanometer sizes enable us to solve many of the inherent problems (stability, solubility, toxicity) associated with natural products, and also provide a platform for targeted delivery to tumor sites. We recently introduced the novel concept of using nanotechnology for enhancing the outcome of chemoprevention, which we called ‘nanochemoprevention’. This idea was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the applications of nanotechnology for cancer prevention and therapy using natural products.http://www.mdpi.com/2072-6694/3/4/4024/nanoparticlescancerchemopreventionnatural productepigallocatechin-3-gallatecurcuminresveratroltaxolcamptothecin
spellingShingle Hasan Mukhtar
Dhruba J. Bharali
Imtiaz A. Siddiqui
Vaqar M. Adhami
Jean Christopher Chamcheu
Abdullah M. Aldahmash
Shaker A. Mousa
Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
Cancers
nanoparticles
cancer
chemoprevention
natural product
epigallocatechin-3-gallate
curcumin
resveratrol
taxol
camptothecin
title Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
title_full Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
title_fullStr Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
title_full_unstemmed Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
title_short Nanoparticle Delivery of Natural Products in the Prevention and Treatment of Cancers: Current Status and Future Prospects
title_sort nanoparticle delivery of natural products in the prevention and treatment of cancers current status and future prospects
topic nanoparticles
cancer
chemoprevention
natural product
epigallocatechin-3-gallate
curcumin
resveratrol
taxol
camptothecin
url http://www.mdpi.com/2072-6694/3/4/4024/
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