Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key player...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/12/1987 |
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| author | Nagabhishek Sirpu Natesh Brianna M. White Maia M. C. Bennett Metin Uz Rakhee Rathnam Kalari Kandy Surinder K. Batra Surya K. Mallapragada Satyanarayana Rachagani |
| author_facet | Nagabhishek Sirpu Natesh Brianna M. White Maia M. C. Bennett Metin Uz Rakhee Rathnam Kalari Kandy Surinder K. Batra Surya K. Mallapragada Satyanarayana Rachagani |
| author_sort | Nagabhishek Sirpu Natesh |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key players regulating cancer pathogenesis. Dysregulated miRNAs are associated with molecular pathways involved in tumor development, metastasis, and chemoresistance in PDAC, as well as other cancers. Targeted treatment strategies that alter miRNA levels in cancers have promising potential as therapeutic interventions. miRNA-345 (miR-345) plays a critical role in tumor suppression and is differentially expressed in various cancers, including pancreatic cancer (PC). The underlying mechanism(s) and delivery strategies of miR-345 have been investigated by us previously. Here, we summarize the potential therapeutic roles of miR-345 in different cancers, with emphasis on PDAC, for miRNA drug discovery, development, status, and implications. Further, we focus on miRNA nanodelivery system(s), based on different materials and nanoformulations, specifically for the delivery of miR-345. |
| first_indexed | 2024-03-10T03:20:37Z |
| format | Article |
| id | doaj.art-9cea848270274aabae979cde49339b95 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:20:37Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9cea848270274aabae979cde49339b952023-11-23T10:04:21ZengMDPI AGPharmaceutics1999-49232021-11-011312198710.3390/pharmaceutics13121987Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other CancersNagabhishek Sirpu Natesh0Brianna M. White1Maia M. C. Bennett2Metin Uz3Rakhee Rathnam Kalari Kandy4Surinder K. Batra5Surya K. Mallapragada6Satyanarayana Rachagani7Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USADepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USADepartment of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH 44115-2214, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USADepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USAPancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key players regulating cancer pathogenesis. Dysregulated miRNAs are associated with molecular pathways involved in tumor development, metastasis, and chemoresistance in PDAC, as well as other cancers. Targeted treatment strategies that alter miRNA levels in cancers have promising potential as therapeutic interventions. miRNA-345 (miR-345) plays a critical role in tumor suppression and is differentially expressed in various cancers, including pancreatic cancer (PC). The underlying mechanism(s) and delivery strategies of miR-345 have been investigated by us previously. Here, we summarize the potential therapeutic roles of miR-345 in different cancers, with emphasis on PDAC, for miRNA drug discovery, development, status, and implications. Further, we focus on miRNA nanodelivery system(s), based on different materials and nanoformulations, specifically for the delivery of miR-345.https://www.mdpi.com/1999-4923/13/12/1987PDACmiR-345miRNA nanodelivery |
| spellingShingle | Nagabhishek Sirpu Natesh Brianna M. White Maia M. C. Bennett Metin Uz Rakhee Rathnam Kalari Kandy Surinder K. Batra Surya K. Mallapragada Satyanarayana Rachagani Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers Pharmaceutics PDAC miR-345 miRNA nanodelivery |
| title | Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers |
| title_full | Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers |
| title_fullStr | Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers |
| title_full_unstemmed | Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers |
| title_short | Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers |
| title_sort | emerging role of mir 345 and its effective delivery as a potential therapeutic candidate in pancreatic cancer and other cancers |
| topic | PDAC miR-345 miRNA nanodelivery |
| url | https://www.mdpi.com/1999-4923/13/12/1987 |
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