Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx–m6A editor inhibits bladder cancer development

Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx–m6A editor inhibits bladder cancer development

Introduction: N6-methyladenosine (m6A) modification contributes to the pathogenesis and development of various cancers, including bladder cancer (BCa). In particular, integrin α6 (ITGA6) promotes BCa progression by cooperatively regulating multisite m6A modification. However, the therapeutic effect...

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Bibliographic Details
Main Authors: Xiaoling Ying, Yapeng Huang, Bixia Liu, WenYu Hu, Ding Ji, Cong Chen, Haiqing Zhang, Yaomin liang, Yifan lv, Weidong Ji
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Journal of Advanced Research
Subjects:
dCasRx
N6-methyladenosine
Multisite
ITGA6
Bladder cancer
Adeno-associated viral
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223000929

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http://www.sciencedirect.com/science/article/pii/S2090123223000929

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