Immunological basis of vaccination
The basic mechanisms of body defences against infectious diseases are both non- specific and specific immune systems. Non- specific immunity refers to mechanism of protection that do not require specific recognition of antigen, but that increase the protection afforded by specific immune mechanisms....
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2016-09-01
|
| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/684 |
| Summary: | The basic mechanisms of body defences
against infectious diseases are both non-
specific and specific immune systems. Non-
specific immunity refers to mechanism of
protection that do not require specific recognition of
antigen, but that increase the protection afforded by
specific immune mechanisms. Non-specific immune
mechanisms include phagocytes, acute inflammatory
responses, type-1 interferon, and tumour necrosing
factor. Specific immunity consists of mechanisms of
protection that require specific recognition of antigen.
This immunity is highly specific, inducible,
discriminatory and unforgotten T lymphocyte-
dependent response. Normal specific immunity
operates under Major Histocompatibility Complex
restriction. It is the ability of this immune system to
refine its antigen recognition domains and establish
immunological memory that underlies the success of
active vaccination. |
|---|---|
| ISSN: | 0030-9311 2338-476X |