Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area
Abstract Background Hashimoto thyroiditis (HT) is an autoimmune lymphocytic thyroiditis and is the most common form of thyroid inflammatory diseases. The association of HT with papillary thyroid carcinoma (PTC) has been described. PTC is the most common form of malignancy associated with HT. When pa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-01-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43046-020-0017-9 |
| _version_ | 1818427811789012992 |
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| author | Osama Hussein Khaled Abdelwahab Omar Hamdy Shadi Awny Nermin A. Megahed Mohamed T. Hafez Amr F. Elalfi Mahmoud Abdelaziz Khaled Gaballah Mohamed Abdelkhalek |
| author_facet | Osama Hussein Khaled Abdelwahab Omar Hamdy Shadi Awny Nermin A. Megahed Mohamed T. Hafez Amr F. Elalfi Mahmoud Abdelaziz Khaled Gaballah Mohamed Abdelkhalek |
| author_sort | Osama Hussein |
| collection | DOAJ |
| description | Abstract Background Hashimoto thyroiditis (HT) is an autoimmune lymphocytic thyroiditis and is the most common form of thyroid inflammatory diseases. The association of HT with papillary thyroid carcinoma (PTC) has been described. PTC is the most common form of malignancy associated with HT. When papillary carcinoma develops on top of Hashimoto thyroiditis, the disease tends to be less aggressive and lymph node and extra-thyroidal invasion are infrequent. Results We retrospectively examined the pathological features of our patients who were diagnosed with concomitant HT and thyroid cancer. In Egyptian patients, PTC was the main type of malignancy associated with HT (96.2%) and was often multifocal (46.2%). In contrast to the published literature, lymph node invasion and extra-thyroidal extension were as frequent in association with HT as in other cancer cohorts. We also observed the frequent occurrence of Hürthle cell metaplasia (23.1%) and the appreciable incidence of aggressive histological types of PTC (32%). Conclusion Thyroid carcinoma with HT may have some aggressive features in areas with endemic goiter background. |
| first_indexed | 2024-12-14T14:51:40Z |
| format | Article |
| id | doaj.art-9ced972d267d440cad29e490044667e2 |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-12-14T14:51:40Z |
| publishDate | 2020-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-9ced972d267d440cad29e490044667e22022-12-21T22:57:08ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092020-01-013211410.1186/s43046-020-0017-9Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic areaOsama Hussein0Khaled Abdelwahab1Omar Hamdy2Shadi Awny3Nermin A. Megahed4Mohamed T. Hafez5Amr F. Elalfi6Mahmoud Abdelaziz7Khaled Gaballah8Mohamed Abdelkhalek9Surgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerPathology department, Mansoura University Faculty of MedicineSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerSurgical oncology unit, Mansoura University Oncology centerAbstract Background Hashimoto thyroiditis (HT) is an autoimmune lymphocytic thyroiditis and is the most common form of thyroid inflammatory diseases. The association of HT with papillary thyroid carcinoma (PTC) has been described. PTC is the most common form of malignancy associated with HT. When papillary carcinoma develops on top of Hashimoto thyroiditis, the disease tends to be less aggressive and lymph node and extra-thyroidal invasion are infrequent. Results We retrospectively examined the pathological features of our patients who were diagnosed with concomitant HT and thyroid cancer. In Egyptian patients, PTC was the main type of malignancy associated with HT (96.2%) and was often multifocal (46.2%). In contrast to the published literature, lymph node invasion and extra-thyroidal extension were as frequent in association with HT as in other cancer cohorts. We also observed the frequent occurrence of Hürthle cell metaplasia (23.1%) and the appreciable incidence of aggressive histological types of PTC (32%). Conclusion Thyroid carcinoma with HT may have some aggressive features in areas with endemic goiter background.https://doi.org/10.1186/s43046-020-0017-9Thyroid cancerHashimoto’s thyroiditisPapillary thyroid carcinomaEndemic goiterEgypt |
| spellingShingle | Osama Hussein Khaled Abdelwahab Omar Hamdy Shadi Awny Nermin A. Megahed Mohamed T. Hafez Amr F. Elalfi Mahmoud Abdelaziz Khaled Gaballah Mohamed Abdelkhalek Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area Journal of the Egyptian National Cancer Institute Thyroid cancer Hashimoto’s thyroiditis Papillary thyroid carcinoma Endemic goiter Egypt |
| title | Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area |
| title_full | Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area |
| title_fullStr | Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area |
| title_full_unstemmed | Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area |
| title_short | Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area |
| title_sort | thyroid cancer associated with hashimoto thyroiditis similarities and differences in an endemic area |
| topic | Thyroid cancer Hashimoto’s thyroiditis Papillary thyroid carcinoma Endemic goiter Egypt |
| url | https://doi.org/10.1186/s43046-020-0017-9 |
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