Revisiting the Overlooked Infection: Rickettsioses
The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence o...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-12-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2068 |
| _version_ | 1828067142888587264 |
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| author | Khie Chen Lie Erni Juwita Nelwan Adeline Pasaribu Sharifah Shakinah Robert Sinto Leonard Nainggolan |
| author_facet | Khie Chen Lie Erni Juwita Nelwan Adeline Pasaribu Sharifah Shakinah Robert Sinto Leonard Nainggolan |
| author_sort | Khie Chen Lie |
| collection | DOAJ |
| description | The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease. |
| first_indexed | 2024-04-10T23:41:39Z |
| format | Article |
| id | doaj.art-9cef3b61066f477fa39e4ca6ddebc8dc |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-04-10T23:41:39Z |
| publishDate | 2022-12-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-9cef3b61066f477fa39e4ca6ddebc8dc2023-01-11T07:11:42ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-12-01544560Revisiting the Overlooked Infection: RickettsiosesKhie Chen Lie0Erni Juwita Nelwan1Adeline Pasaribu2Sharifah Shakinah3Robert Sinto4Leonard Nainggolan51. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Member of Antimicrobial Stewardship Committee, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Member of Antimicrobial Stewardship Committee, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Member of Antimicrobial Stewardship Committee, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.1. Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Member of Antimicrobial Stewardship Committee, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.The prevalence of human Rickettsioses cases in Indonesia is unknown and could probably be underestimated. The high prevalence of seropositive Rickettsia sp. was reported in small mammals (as vectors) and humans. In Indonesia, a recent study in patients with acute fever revealed that the prevalence of Rickettsioses is 10%. Many cases of Rickettsioses were often misdiagnosed with dengue fever, enteric fever, or leptospirosis due to their overlapping clinical manifestation. The limitation of point of care testing in Indonesia hindered the adequacy of diagnosis confirmation. Appropriate empirical or definitive treatment with macrolide, mainly doxycycline, is preferable compared to other broad-spectrum antibiotics, such as cephalosporin or quinolones. Moreover, when left untreated, Rickettsioses may deteriorate progressively to fatal outcomes, such as meningitis, sepsis, and even death. The awareness of health care practitioners, the availability of confirmatory rapid diagnostic tests and adequate treatment choices are important in eradicating this disease.https://actamedindones.org/index.php/ijim/article/view/2068internal medicinetropical diseaseinfectionrickettsioses |
| spellingShingle | Khie Chen Lie Erni Juwita Nelwan Adeline Pasaribu Sharifah Shakinah Robert Sinto Leonard Nainggolan Revisiting the Overlooked Infection: Rickettsioses Acta Medica Indonesiana internal medicine tropical disease infection rickettsioses |
| title | Revisiting the Overlooked Infection: Rickettsioses |
| title_full | Revisiting the Overlooked Infection: Rickettsioses |
| title_fullStr | Revisiting the Overlooked Infection: Rickettsioses |
| title_full_unstemmed | Revisiting the Overlooked Infection: Rickettsioses |
| title_short | Revisiting the Overlooked Infection: Rickettsioses |
| title_sort | revisiting the overlooked infection rickettsioses |
| topic | internal medicine tropical disease infection rickettsioses |
| url | https://actamedindones.org/index.php/ijim/article/view/2068 |
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