Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study
Abstract Background While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC. Methods Data of 81 patients with histopathologically proven...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1556-6 |
| _version_ | 1818514096270606336 |
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| author | Jin-Kyu Cho Woohyung Lee Jae Yool Jang Han-Gil Kim Jae-Myung Kim Seung-Jin Kwag Ji-Ho Park Ju-Yeon Kim Taejin Park Sang-Ho Jeong Young-Tae Ju Eun-Jung Jung Young-Joon Lee Soon-Chan Hong Chi-Young Jeong |
| author_facet | Jin-Kyu Cho Woohyung Lee Jae Yool Jang Han-Gil Kim Jae-Myung Kim Seung-Jin Kwag Ji-Ho Park Ju-Yeon Kim Taejin Park Sang-Ho Jeong Young-Tae Ju Eun-Jung Jung Young-Joon Lee Soon-Chan Hong Chi-Young Jeong |
| author_sort | Jin-Kyu Cho |
| collection | DOAJ |
| description | Abstract Background While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC. Methods Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Of these, 36 patients had peritoneal-side (T2a) tumors and 45 had hepatic-side (T2b) tumors. To identify the optimal surgical management method, T2 GBC patients were classified into the hepatic resection group (n = 44, T2a/T2b = 20/24) and non-hepatic resection group (n = 37, T2a/T2b = 16/21). The recurrence pattern and role of hepatic resection for T2 GBC were then investigated. Results Mean age of the patients was 69 (range 36–88) years, and the male-to-female ratio was 42:39 (male, 51.9%; female, 48.1%). Hepatic-side GBC had a higher rate of recurrence than peritoneal-side GBC (44.4% vs. 8.3%, p = 0.006). The most common type of recurrence in T2a GBC was para-aortic lymph node recurrence (n = 2, 5.6%); the most common types of recurrence in T2b GBC were para-aortic lymph node recurrence (n = 7, 15.6%) and intrahepatic metastasis (n = 6, 13.3%). Hepatic-side GBC patients had worse survival outcomes than peritoneal-side GBC patients (76.0% vs. 96.6%, p = 0.041). Hepatic resection had no significant treatment effect in T2 GBC patients (p = 0.272). Multivariate analysis showed that lymph node metastasis was the only significant prognostic factor (p = 0.002). Conclusions Hepatic resection is not essential for curative treatment in T2 GBC, and more systemic treatments are needed for GBC patients, particularly for those with T2b GBC. |
| first_indexed | 2024-12-11T00:10:31Z |
| format | Article |
| id | doaj.art-9cef5825a68f479e88ace62a19d51bc5 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-11T00:10:31Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-9cef5825a68f479e88ace62a19d51bc52022-12-22T01:28:09ZengBMCWorld Journal of Surgical Oncology1477-78192019-01-0117111110.1186/s12957-018-1556-6Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective studyJin-Kyu Cho0Woohyung Lee1Jae Yool Jang2Han-Gil Kim3Jae-Myung Kim4Seung-Jin Kwag5Ji-Ho Park6Ju-Yeon Kim7Taejin Park8Sang-Ho Jeong9Young-Tae Ju10Eun-Jung Jung11Young-Joon Lee12Soon-Chan Hong13Chi-Young Jeong14Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineDepartment of Surgery, Gyeongsang National University Hospital, Gyeongsang National University Postgraduate School of MedicineAbstract Background While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection for T2 GBC is unclear. This study aimed to identify the necessity of hepatic resection in patients with T2 GBC. Methods Data of 81 patients with histopathologically proven T2 GBC who underwent surgical resection between January 1999 and December 2017 were enrolled from a retrospective database. Of these, 36 patients had peritoneal-side (T2a) tumors and 45 had hepatic-side (T2b) tumors. To identify the optimal surgical management method, T2 GBC patients were classified into the hepatic resection group (n = 44, T2a/T2b = 20/24) and non-hepatic resection group (n = 37, T2a/T2b = 16/21). The recurrence pattern and role of hepatic resection for T2 GBC were then investigated. Results Mean age of the patients was 69 (range 36–88) years, and the male-to-female ratio was 42:39 (male, 51.9%; female, 48.1%). Hepatic-side GBC had a higher rate of recurrence than peritoneal-side GBC (44.4% vs. 8.3%, p = 0.006). The most common type of recurrence in T2a GBC was para-aortic lymph node recurrence (n = 2, 5.6%); the most common types of recurrence in T2b GBC were para-aortic lymph node recurrence (n = 7, 15.6%) and intrahepatic metastasis (n = 6, 13.3%). Hepatic-side GBC patients had worse survival outcomes than peritoneal-side GBC patients (76.0% vs. 96.6%, p = 0.041). Hepatic resection had no significant treatment effect in T2 GBC patients (p = 0.272). Multivariate analysis showed that lymph node metastasis was the only significant prognostic factor (p = 0.002). Conclusions Hepatic resection is not essential for curative treatment in T2 GBC, and more systemic treatments are needed for GBC patients, particularly for those with T2b GBC.http://link.springer.com/article/10.1186/s12957-018-1556-6Gallbladder carcinomaSurgical strategiesHepatic resection |
| spellingShingle | Jin-Kyu Cho Woohyung Lee Jae Yool Jang Han-Gil Kim Jae-Myung Kim Seung-Jin Kwag Ji-Ho Park Ju-Yeon Kim Taejin Park Sang-Ho Jeong Young-Tae Ju Eun-Jung Jung Young-Joon Lee Soon-Chan Hong Chi-Young Jeong Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study World Journal of Surgical Oncology Gallbladder carcinoma Surgical strategies Hepatic resection |
| title | Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study |
| title_full | Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study |
| title_fullStr | Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study |
| title_full_unstemmed | Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study |
| title_short | Validation of the oncologic effect of hepatic resection for T2 gallbladder cancer: a retrospective study |
| title_sort | validation of the oncologic effect of hepatic resection for t2 gallbladder cancer a retrospective study |
| topic | Gallbladder carcinoma Surgical strategies Hepatic resection |
| url | http://link.springer.com/article/10.1186/s12957-018-1556-6 |
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