Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects
Introduction: Peyronie’s disease (PD) is a chronic wound-healing disorder characterized by formation of fibrous inelastic scarring of the tunica albuginea resulting in a variety of penile deformities. In most cases, PD is accompanied by a physical and psychological impact. Xiaflex® is an injectable...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-10-01
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| Series: | Therapeutic Advances in Urology |
| Online Access: | https://doi.org/10.1177/1756287214537331 |
| _version_ | 1818974845277306880 |
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| author | María Alejandra Egui Rojo Ignacio Moncada Iribarren Joaquín Carballido Rodriguez Juan Ignacio Martinez-Salamanca |
| author_facet | María Alejandra Egui Rojo Ignacio Moncada Iribarren Joaquín Carballido Rodriguez Juan Ignacio Martinez-Salamanca |
| author_sort | María Alejandra Egui Rojo |
| collection | DOAJ |
| description | Introduction: Peyronie’s disease (PD) is a chronic wound-healing disorder characterized by formation of fibrous inelastic scarring of the tunica albuginea resulting in a variety of penile deformities. In most cases, PD is accompanied by a physical and psychological impact. Xiaflex® is an injectable collagenase clostridium histolyticum (CCh) preparation consisting of a predetermined mixture of two distinct collagenases. Recently the US Food and Drug Administration (FDA) approved Xiaflex® for the nonsurgical treatment of men with PD with curvature of 30° or more and tangible scar tissue plaque in their penis. Method: This article presents a comprehensive review of the updated information on the use of Xiaflex® for the nonsurgical treatment of PD. Results: Mean improvements in penile curvature ranging from 29% to 34% and in bother domain scores have been reported. The majority of the reported adverse effects are mild or moderate and 79% resolve without intervention. Conclusion: The combined results of these trials have led to the FDA approval of CCh for the treatment of PD. However, the long-term effects and results need further investigation, with large follow-up series. Considering these results, future perspectives will probably result in the use of a combined or sequential therapy including CCh. |
| first_indexed | 2024-12-20T15:46:32Z |
| format | Article |
| id | doaj.art-9cf0508544d943bc88382b7cfeafde05 |
| institution | Directory Open Access Journal |
| issn | 1756-2872 1756-2880 |
| language | English |
| last_indexed | 2024-12-20T15:46:32Z |
| publishDate | 2014-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Urology |
| spelling | doaj.art-9cf0508544d943bc88382b7cfeafde052022-12-21T19:34:55ZengSAGE PublishingTherapeutic Advances in Urology1756-28721756-28802014-10-01610.1177/1756287214537331Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospectsMaría Alejandra Egui RojoIgnacio Moncada IribarrenJoaquín Carballido RodriguezJuan Ignacio Martinez-SalamancaIntroduction: Peyronie’s disease (PD) is a chronic wound-healing disorder characterized by formation of fibrous inelastic scarring of the tunica albuginea resulting in a variety of penile deformities. In most cases, PD is accompanied by a physical and psychological impact. Xiaflex® is an injectable collagenase clostridium histolyticum (CCh) preparation consisting of a predetermined mixture of two distinct collagenases. Recently the US Food and Drug Administration (FDA) approved Xiaflex® for the nonsurgical treatment of men with PD with curvature of 30° or more and tangible scar tissue plaque in their penis. Method: This article presents a comprehensive review of the updated information on the use of Xiaflex® for the nonsurgical treatment of PD. Results: Mean improvements in penile curvature ranging from 29% to 34% and in bother domain scores have been reported. The majority of the reported adverse effects are mild or moderate and 79% resolve without intervention. Conclusion: The combined results of these trials have led to the FDA approval of CCh for the treatment of PD. However, the long-term effects and results need further investigation, with large follow-up series. Considering these results, future perspectives will probably result in the use of a combined or sequential therapy including CCh.https://doi.org/10.1177/1756287214537331 |
| spellingShingle | María Alejandra Egui Rojo Ignacio Moncada Iribarren Joaquín Carballido Rodriguez Juan Ignacio Martinez-Salamanca Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects Therapeutic Advances in Urology |
| title | Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects |
| title_full | Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects |
| title_fullStr | Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects |
| title_full_unstemmed | Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects |
| title_short | Experience in the use of collagenase clostridium histolyticum in the management of Peyronie’s disease: current data and future prospects |
| title_sort | experience in the use of collagenase clostridium histolyticum in the management of peyronie s disease current data and future prospects |
| url | https://doi.org/10.1177/1756287214537331 |
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