Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs
Like humans, the accumulation of amyloid-beta oligomers in the brains of aged dogs leads to cognitive dysfunction. Our study investigated the effects of dietary flavonoids in pet foods on cognitive dysfunction. All nine dogs (six species) recruited were older than seven years, and cognitive function...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/23/12130 |
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| author | Mi-Jin Lee Miey Park Hae-Jeung Lee |
| author_facet | Mi-Jin Lee Miey Park Hae-Jeung Lee |
| author_sort | Mi-Jin Lee |
| collection | DOAJ |
| description | Like humans, the accumulation of amyloid-beta oligomers in the brains of aged dogs leads to cognitive dysfunction. Our study investigated the effects of dietary flavonoids in pet foods on cognitive dysfunction. All nine dogs (six species) recruited were older than seven years, and cognitive function was measured using a questionnaire before and after applying pet food containing <i>cyanidin-3-O-glucoside</i>, the main component of honeyberries. Physical examination, blood tests, cognitive dysfunction scores, and serum amyloid-beta oligomers were measured. After 90 days of pet food administration, a physical examination revealed no abnormalities in weight, body temperature, heart rate, or respiratory rate. However, the cognitive dysfunction score and serum amyloid-beta oligomers (AβO) marker levels were significantly reduced after 90 days. Inflammation and antioxidant levels were slightly, but not significantly, changed. Our results suggest that pet food containing anthocyanins effectively improves cognitive dysfunction scores and decreases serum AβO levels. |
| first_indexed | 2024-03-09T17:53:29Z |
| format | Article |
| id | doaj.art-9cf17648f3c345bdaaa49626cbc8b9ae |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T17:53:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9cf17648f3c345bdaaa49626cbc8b9ae2023-11-24T10:31:28ZengMDPI AGApplied Sciences2076-34172022-11-0112231213010.3390/app122312130Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly DogsMi-Jin Lee0Miey Park1Hae-Jeung Lee2Mammidr Corporation, Seongnam-si 13524, Republic of KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam-si 13120, Republic of KoreaLike humans, the accumulation of amyloid-beta oligomers in the brains of aged dogs leads to cognitive dysfunction. Our study investigated the effects of dietary flavonoids in pet foods on cognitive dysfunction. All nine dogs (six species) recruited were older than seven years, and cognitive function was measured using a questionnaire before and after applying pet food containing <i>cyanidin-3-O-glucoside</i>, the main component of honeyberries. Physical examination, blood tests, cognitive dysfunction scores, and serum amyloid-beta oligomers were measured. After 90 days of pet food administration, a physical examination revealed no abnormalities in weight, body temperature, heart rate, or respiratory rate. However, the cognitive dysfunction score and serum amyloid-beta oligomers (AβO) marker levels were significantly reduced after 90 days. Inflammation and antioxidant levels were slightly, but not significantly, changed. Our results suggest that pet food containing anthocyanins effectively improves cognitive dysfunction scores and decreases serum AβO levels.https://www.mdpi.com/2076-3417/12/23/12130pet food<i>cyanidin-3-O-glucoside</i>cognitive dysfunction scoreserum AβO |
| spellingShingle | Mi-Jin Lee Miey Park Hae-Jeung Lee Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs Applied Sciences pet food <i>cyanidin-3-O-glucoside</i> cognitive dysfunction score serum AβO |
| title | Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs |
| title_full | Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs |
| title_fullStr | Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs |
| title_full_unstemmed | Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs |
| title_short | Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs |
| title_sort | dietary supplemented anthocyanin reduced serum amyloid beta oligomers and improved cognitive dysfunction scores in elderly dogs |
| topic | pet food <i>cyanidin-3-O-glucoside</i> cognitive dysfunction score serum AβO |
| url | https://www.mdpi.com/2076-3417/12/23/12130 |
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