Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension
Aim. То study 12-week spirapril (Quadropril®) therapy effectiveness in patients with mild to moderate arterial hypertension (АП). Material and metliods. For 12 weeks, 62 patients with mild to moderate АП received spirapril (6 mg/d), with diuretics (hydrochlorthiazide or Arifon retard) added if antih...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1527 |
| _version_ | 1827064180949123072 |
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| author | M. M. Beraya V. V. Petriy N. G. Sergushkina V. I. Makolkin |
| author_facet | M. M. Beraya V. V. Petriy N. G. Sergushkina V. I. Makolkin |
| author_sort | M. M. Beraya |
| collection | DOAJ |
| description | Aim. То study 12-week spirapril (Quadropril®) therapy effectiveness in patients with mild to moderate arterial hypertension (АП). Material and metliods. For 12 weeks, 62 patients with mild to moderate АП received spirapril (6 mg/d), with diuretics (hydrochlorthiazide or Arifon retard) added if antihypertensive effect was insufficient. Results. Blood pressure (BP) normalized in 25,8% of the patients. Adding diuretics (hydrochlorthiazide, 25 mg/d, or Arifon® retard, 1,5 mg/d) normalized BP in the rest of the participants. Circadian BP rhythm was also normalized. Spirapril was well tolerated by the patients. Conclusion. ACE inhibitor spirapril (Quadropril®) effectively normalizes BP in patients with mild to moderate АП. In case of insufficient antihypertensive effect, combination with diuretics allows to normalize BP in extra 87% of the patients. |
| first_indexed | 2024-04-10T03:41:53Z |
| format | Article |
| id | doaj.art-9cf2989c7b894f8597469ce57a7334b1 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:43:03Z |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-9cf2989c7b894f8597469ce57a7334b12024-10-17T12:21:21Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-015822281245Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertensionM. M. Beraya0V. V. Petriy1N. G. Sergushkina2V. I. Makolkin3I.M. Sechenov Moscow Medical Academy. MoscowI.M. Sechenov Moscow Medical Academy. MoscowI.M. Sechenov Moscow Medical Academy. MoscowI.M. Sechenov Moscow Medical Academy. MoscowAim. То study 12-week spirapril (Quadropril®) therapy effectiveness in patients with mild to moderate arterial hypertension (АП). Material and metliods. For 12 weeks, 62 patients with mild to moderate АП received spirapril (6 mg/d), with diuretics (hydrochlorthiazide or Arifon retard) added if antihypertensive effect was insufficient. Results. Blood pressure (BP) normalized in 25,8% of the patients. Adding diuretics (hydrochlorthiazide, 25 mg/d, or Arifon® retard, 1,5 mg/d) normalized BP in the rest of the participants. Circadian BP rhythm was also normalized. Spirapril was well tolerated by the patients. Conclusion. ACE inhibitor spirapril (Quadropril®) effectively normalizes BP in patients with mild to moderate АП. In case of insufficient antihypertensive effect, combination with diuretics allows to normalize BP in extra 87% of the patients.https://cardiovascular.elpub.ru/jour/article/view/1527arterial hypertensionspiraprilcircadian blood pressure rhythmcombined therapy |
| spellingShingle | M. M. Beraya V. V. Petriy N. G. Sergushkina V. I. Makolkin Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension Кардиоваскулярная терапия и профилактика arterial hypertension spirapril circadian blood pressure rhythm combined therapy |
| title | Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| title_full | Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| title_fullStr | Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| title_full_unstemmed | Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| title_short | Antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| title_sort | antihypertensive spirapril effectiveness in patients with mild to moderate arterial hypertension |
| topic | arterial hypertension spirapril circadian blood pressure rhythm combined therapy |
| url | https://cardiovascular.elpub.ru/jour/article/view/1527 |
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