Cthrc1 is a positive regulator of osteoblastic bone formation.

Cthrc1 is a positive regulator of osteoblastic bone formation.

Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix repeat containing-1 (Cthrc1) as a downstream targe...

Full description

Bibliographic Details
Main Authors:	Hiroaki Kimura, Kin Ming Kwan, Zhaoping Zhang, Jian Min Deng, Bryant G Darnay, Richard R Behringer, Takashi Nakamura, Benoit de Crombrugghe, Haruhiko Akiyama
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-09-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2527134?pdf=render

Similar Items

Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.
by: Xin Zhou, et al.
Published: (2014-12-01)

The role of CTHRC1 in promotion of cutaneous wound healing
by: Xianlan Duan, et al.
Published: (2022-06-01)

Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix.
by: Qin Chen, et al.
Published: (2013-01-01)

CTHRC1: An Emerging Hallmark of Pathogenic Fibroblasts in Lung Fibrosis
by: Zhussipbek Mukhatayev, et al.
Published: (2024-05-01)

Cthrc1, a novel circulating hormone regulating metabolism.
by: J Patrizia Stohn, et al.
Published: (2012-01-01)

Assessment of Plasma Level of CTHRC-I in Patients with Rheumatoid Arthritis
by: Sahar Alwan, et al.
Published: (2021-12-01)

Osteoblast-Specific Overexpression of Nucleolar Protein NO66/RIOX1 in Mouse Embryos Leads to Osteoporosis in Adult Mice
by: Qin Chen, et al.
Published: (2023-01-01)

Akt1 in osteoblasts and osteoclasts controls bone remodeling.
by: Naohiro Kawamura, et al.
Published: (2007-10-01)

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis
by: Dan Mei, et al.
Published: (2020-01-01)

CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway
by: Cheng Chen, et al.
Published: (2024-12-01)

CTHRC1 modulates cell proliferation and invasion in hepatocellular carcinoma by DNA methylation
by: Xiangjun Sun, et al.
Published: (2024-08-01)

Estimation levels of CTHRC1and some cytokines in Iraqi patients with Rheumatoid Arthritis
by: Ahmed R. Oleiwi, et al.
Published: (2023-06-01)

CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis
by: Askhat Myngbay, et al.
Published: (2019-06-01)

Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma
by: Chen Pang, et al.
Published: (2022-03-01)

A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma
by: Songling Han, et al.
Published: (2021-08-01)

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
by: Guiqian Chen, Chuxia Deng, Yi-Ping Li
Published: (2012-01-01)

Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis.
by: Yu-Ling Chen, et al.
Published: (2013-01-01)

The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets
by: Lulu Zhao, et al.
Published: (2022-07-01)

CTHRC1 is a Potential Prognostic Biomarker and Correlated with Macrophage Infiltration in Breast Cancer
by: Wang Z, et al.
Published: (2022-06-01)

CTHRC1 is a prognosis-related biomarker correlated with immune infiltrates in colon adenocarcinoma
by: Chuang Meng, et al.
Published: (2022-03-01)

Impaired Alignment of Bone Matrix Microstructure Associated with Disorganized Osteoblast Arrangement in Malignant Melanoma Metastasis
by: Aira Matsugaki, et al.
Published: (2021-01-01)

Osteoblastic Solitary Plasmacytoma of Bone
by: Chrissa Sioka, et al.
Published: (2019-05-01)

The role of osteoblasts in bone metastasis
by: Penelope D Ottewell
Published: (2016-09-01)

CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer
by: Shujuan Ni, et al.
Published: (2018-11-01)

Boric acid inhibits alveolar bone loss in rat experimental periodontitis through diminished bone resorption and enhanced osteoblast formation
by: Nazmus Shalehin, et al.
Published: (2020-12-01)

Osteoblast-Osteoclast Communication and Bone Homeostasis
by: Jung-Min Kim, et al.
Published: (2020-09-01)

Osteoblasts in Bone Physiology—Mini Review
by: Orit Rosenberg, et al.
Published: (2012-04-01)

Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
by: Hyo Min Jeong, et al.
Published: (2016-12-01)

CTHRC1 is a prognostic biomarker correlated with immune infiltration in head and neck squamous cell carcinoma
by: Zhichao Zhang, et al.
Published: (2024-06-01)

CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells
by: Yong Chen, et al.
Published: (2023-05-01)

CTHRC1+ fibroblasts are stimulated by macrophage‐secreted SPP1 to induce excessive collagen deposition in keloids
by: Jing Liu, et al.
Published: (2022-12-01)

Activation of CTHRC1 by HOXB9 promotes angiogenesis through fatty acid metabolism in lung adenocarcinoma
by: Keqi Liu, et al.
Published: (2023-04-01)

Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors.
by: Christine W Duarte, et al.
Published: (2014-01-01)

Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers
by: Dazhao Peng, et al.
Published: (2021-10-01)

Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin
by: Nicole Cudak, et al.
Published: (2024-02-01)

Tridax procumbens flavonoids promote osteoblast differentiation and bone formation
by: Md. Abdullah Al Mamun, et al.

Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts
by: F Shapiro
Published: (2008-04-01)

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients
by: Yangshan Chen, et al.
Published: (2019-11-01)

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
by: Qiong Zhu, et al.
Published: (2023-04-01)

Bone marrow osteoblast damage by chemotherapeutic agents.
by: Stephanie L Rellick, et al.
Published: (2012-01-01)