Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures
ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26972-8 |
| _version_ | 1819005533615554560 |
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| author | Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan |
| author_facet | Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan |
| author_sort | Luye Qin |
| collection | DOAJ |
| description | ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inhibition balance. |
| first_indexed | 2024-12-20T23:54:18Z |
| format | Article |
| id | doaj.art-9cf490f4547141f4a572a7d190a6884a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T23:54:18Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9cf490f4547141f4a572a7d190a6884a2022-12-21T19:22:46ZengNature PortfolioNature Communications2041-17232021-11-0112111410.1038/s41467-021-26972-8Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizuresLuye Qin0Jamal B. Williams1Tao Tan2Tiaotiao Liu3Qing Cao4Kaijie Ma5Zhen Yan6Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical SciencesASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic and pharmacological restoration of excitation/inhibition balance.https://doi.org/10.1038/s41467-021-26972-8 |
| spellingShingle | Luye Qin Jamal B. Williams Tao Tan Tiaotiao Liu Qing Cao Kaijie Ma Zhen Yan Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures Nature Communications |
| title | Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures |
| title_full | Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures |
| title_fullStr | Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures |
| title_full_unstemmed | Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures |
| title_short | Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures |
| title_sort | deficiency of autism risk factor ash1l in prefrontal cortex induces epigenetic aberrations and seizures |
| url | https://doi.org/10.1038/s41467-021-26972-8 |
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