Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review
IntroductionParagangliomas of the gallbladder are exceptionally rare. To date, only a few cases of this disease have been reported globally, and the majority were found incidentally during surgery. Although complete resection can achieve a curative effect, specific targeted drugs may have survival b...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031112/full |
| _version_ | 1797942731638571008 |
|---|---|
| author | Yijun Xia Shi Wang Xidong Wang Jiya Du Lei Zhang Long Xia |
| author_facet | Yijun Xia Shi Wang Xidong Wang Jiya Du Lei Zhang Long Xia |
| author_sort | Yijun Xia |
| collection | DOAJ |
| description | IntroductionParagangliomas of the gallbladder are exceptionally rare. To date, only a few cases of this disease have been reported globally, and the majority were found incidentally during surgery. Although complete resection can achieve a curative effect, specific targeted drugs may have survival benefits for patients with potential recurrence and metastasis risks.Case presentationA 48-year-old woman was scheduled for anatomical central hepatectomy due to the discovery of a liver mass. Surprisingly, a gallbladder tumor accompanied by intrahepatic invasion was found rather than primary liver lesions during the operation. Postoperatively, the lesion was confirmed to be a paraganglioma originating from the gallbladder with intrahepatic invasion detectable on histopathology. After surgery, the patient was treated with a new targeted drug, surufatinib {200 mg, q.d. [quaque die (every day)]}, and no recurrence was observed during the regular follow-up.DiscussionGallbladder paraganglioma is rare and occult, and surgeons do not know it well, so it is easily misdiagnosed before surgery. Postoperative pathological examination is the gold standard for diagnosis.ConclusionGiven that the tumor contained abundant blood sinuses, the early and continuous enhancement of dynamic enhanced CT scanning was its characteristic manifestation. We presented a case in which a primary gallbladder paraganglioma was identified accidentally in a patient who was misdiagnosed with a liver lesion before surgery. Based on our experience in this work, the en bloc resection technique in combination with surufatinib might have a survival benefit to patients at risk of potential recurrence or metastasis; however, further follow-up observations are needed. |
| first_indexed | 2024-04-10T20:12:35Z |
| format | Article |
| id | doaj.art-9cf53d54049945c08b6565b410ef6836 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T20:12:35Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9cf53d54049945c08b6565b410ef68362023-01-26T09:18:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10311121031112Case Report: A rare case of primary paraganglioma of the gallbladder with a literature reviewYijun Xia0Shi Wang1Xidong Wang2Jiya Du3Lei Zhang4Long Xia5Department of Hepatobiliary-Pancreatic-Splenic Surgery, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaDepartment of Hepatobiliary-Pancreatic-Splenic Surgery, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaDepartment of Hepatobiliary-Pancreatic-Splenic Surgery, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaDepartment of Pathology, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaDepartment of Pancreatic-Hepatobiliary Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Hepatobiliary-Pancreatic-Splenic Surgery, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaIntroductionParagangliomas of the gallbladder are exceptionally rare. To date, only a few cases of this disease have been reported globally, and the majority were found incidentally during surgery. Although complete resection can achieve a curative effect, specific targeted drugs may have survival benefits for patients with potential recurrence and metastasis risks.Case presentationA 48-year-old woman was scheduled for anatomical central hepatectomy due to the discovery of a liver mass. Surprisingly, a gallbladder tumor accompanied by intrahepatic invasion was found rather than primary liver lesions during the operation. Postoperatively, the lesion was confirmed to be a paraganglioma originating from the gallbladder with intrahepatic invasion detectable on histopathology. After surgery, the patient was treated with a new targeted drug, surufatinib {200 mg, q.d. [quaque die (every day)]}, and no recurrence was observed during the regular follow-up.DiscussionGallbladder paraganglioma is rare and occult, and surgeons do not know it well, so it is easily misdiagnosed before surgery. Postoperative pathological examination is the gold standard for diagnosis.ConclusionGiven that the tumor contained abundant blood sinuses, the early and continuous enhancement of dynamic enhanced CT scanning was its characteristic manifestation. We presented a case in which a primary gallbladder paraganglioma was identified accidentally in a patient who was misdiagnosed with a liver lesion before surgery. Based on our experience in this work, the en bloc resection technique in combination with surufatinib might have a survival benefit to patients at risk of potential recurrence or metastasis; however, further follow-up observations are needed.https://www.frontiersin.org/articles/10.3389/fonc.2022.1031112/fullgallbladder paragangliomaneuroendocrine neoplasms (NENs)immunohistochemistrydifferential diagnosissurufatinib |
| spellingShingle | Yijun Xia Shi Wang Xidong Wang Jiya Du Lei Zhang Long Xia Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review Frontiers in Oncology gallbladder paraganglioma neuroendocrine neoplasms (NENs) immunohistochemistry differential diagnosis surufatinib |
| title | Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review |
| title_full | Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review |
| title_fullStr | Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review |
| title_full_unstemmed | Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review |
| title_short | Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review |
| title_sort | case report a rare case of primary paraganglioma of the gallbladder with a literature review |
| topic | gallbladder paraganglioma neuroendocrine neoplasms (NENs) immunohistochemistry differential diagnosis surufatinib |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031112/full |
| work_keys_str_mv | AT yijunxia casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview AT shiwang casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview AT xidongwang casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview AT jiyadu casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview AT leizhang casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview AT longxia casereportararecaseofprimaryparagangliomaofthegallbladderwithaliteraturereview |