Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

ABSTRACTNucleic acid vaccines are designed based on genetic sequences (DNA or mRNA) of a target antigen to be expressed in vivo to drive a host immune response. In response to the COVID-19 pandemic, mRNA and DNA vaccines based on the SARS-CoV-2 Spike antigen were developed. Surprisingly, head-to-hea...

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Bibliographic Details
Main Authors: Viviane M. Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W. Kulp, Laurent Humeau, Trevor R. F. Smith
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
DNA vaccines
mRNA vaccines
COVID-19
SARS-CoV-2
immunogenicity
animal models
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2023.2281733

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