A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot-melt extrusion (HME) technique. However, syste...

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Bibliographic Details
Main Authors: Samuel O. Kyeremateng, Kristin Voges, Stefanie Dohrn, Ekaterina Sobich, Ute Lander, Stefan Weber, David Gessner, Rachel C. Evans, Matthias Degenhardt
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
hot-melt extrusion
HME risk classification system
HME process design space
quality-by-design
telmisartan
Online Access:https://www.mdpi.com/1999-4923/14/5/1044

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https://www.mdpi.com/1999-4923/14/5/1044

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