Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication
Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere passive lining or supportive role. In fact, EC contribute to a dynamic network regulat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00328/full |
| _version_ | 1818151622848544768 |
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| author | Thorsten M. Leucker Steven P. Jones |
| author_facet | Thorsten M. Leucker Steven P. Jones |
| author_sort | Thorsten M. Leucker |
| collection | DOAJ |
| description | Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere passive lining or supportive role. In fact, EC contribute to a dynamic network regulating vascular tone, cardiac development, and repair. Two distinct EC types, vascular EC and epicardial EC, possess important structural and signaling properties within both the healthy and diseased myocardium. In this review, we address EC-CM interactions in mature, healthy myocardium, followed by a discussion of diseases characterized by EC dysfunction. Finally, we consider strategies to reverse EC-CM miscommunication to improve patients’ outcomes in various cardiovascular diseases. |
| first_indexed | 2024-12-11T13:41:46Z |
| format | Article |
| id | doaj.art-9cf72e8422114a1dbf23bbdbb8b31063 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T13:41:46Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-9cf72e8422114a1dbf23bbdbb8b310632022-12-22T01:04:43ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-08-01510.3389/fphys.2014.00328107276Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunicationThorsten M. Leucker0Steven P. Jones1University of LouisvilleUniversity of LouisvilleMost studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere passive lining or supportive role. In fact, EC contribute to a dynamic network regulating vascular tone, cardiac development, and repair. Two distinct EC types, vascular EC and epicardial EC, possess important structural and signaling properties within both the healthy and diseased myocardium. In this review, we address EC-CM interactions in mature, healthy myocardium, followed by a discussion of diseases characterized by EC dysfunction. Finally, we consider strategies to reverse EC-CM miscommunication to improve patients’ outcomes in various cardiovascular diseases.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00328/fullcardiomyocytecardiovascular diseaseEndothelial Functionparacrine factorsjuxtacrine communication |
| spellingShingle | Thorsten M. Leucker Steven P. Jones Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication Frontiers in Physiology cardiomyocyte cardiovascular disease Endothelial Function paracrine factors juxtacrine communication |
| title | Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication |
| title_full | Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication |
| title_fullStr | Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication |
| title_full_unstemmed | Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication |
| title_short | Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication |
| title_sort | endothelial dysfunction as a nexus for endothelial cell cardiomyocyte miscommunication |
| topic | cardiomyocyte cardiovascular disease Endothelial Function paracrine factors juxtacrine communication |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00328/full |
| work_keys_str_mv | AT thorstenmleucker endothelialdysfunctionasanexusforendothelialcellcardiomyocytemiscommunication AT stevenpjones endothelialdysfunctionasanexusforendothelialcellcardiomyocytemiscommunication |