Identification of tumor mutation burden-associated molecular and clinical features in cancer by analyzing multi-omics data

Identification of tumor mutation burden-associated molecular and clinical features in cancer by analyzing multi-omics data

BackgroundTumor mutation burden (TMB) has been recognized as a predictive biomarker for immunotherapy response in cancer. Systematic identification of molecular features correlated with TMB is significant, although such investigation remains insufficient.MethodsWe analyzed associations of somatic mu...

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Bibliographic Details
Main Authors: Mengyuan Li, Xuejiao Gao, Xiaosheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
tumor mutation burden
multi-omics
antitumor immunity
cancer immunotherapy
TMB prognostic score
ceRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1090838/full

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