Policosanol ameliorates renal inflammation and pyroptosis in hypercholesterolemic rabbits via modulation of HMGB1/PI3K/mTOR/NLRP3/Caspase-1 pathway

Policosanol ameliorates renal inflammation and pyroptosis in hypercholesterolemic rabbits via modulation of HMGB1/PI3K/mTOR/NLRP3/Caspase-1 pathway

Hyperlipidemia represents a major risk factor for cardiovascular and renal diseases. This study aimed to demonstrate the possible ameliorating effects of policosanol (PC) on renal inflammation and pyroptosis. Eighteen male New Zealand rabbits were randomly divided into 3 groups (n = 6/group), one re...

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Bibliographic Details
Main Authors: Gehad M. Elnagar, Mohamed M. Elseweidy, Nesreen M.I.M. Elkomy, Mohammed M. Keshawy, Ola M. Fathy, Mohammed S. Sobh, Yasmin K. Mahmoud
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Functional Foods
Subjects:
Policosanol
Renal inflammation
Pyroptosis
HMGB1
NLRP3
Caspase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622003206

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