Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides
Abstract<br /> The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The acid hydrazides were convert...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2013-06-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_89812_0e2978fbbc64a93316469d04d5d991b7.pdf |
| _version_ | 1818360170323902464 |
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| author | E. Q. Mahmood O. Th. Ali K. M. Daoud |
| author_facet | E. Q. Mahmood O. Th. Ali K. M. Daoud |
| author_sort | E. Q. Mahmood |
| collection | DOAJ |
| description | Abstract<br /> The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The acid hydrazides were converted to 1- substituted thiosemicarbazides (3,4) by this reaction with ammonium thiocyanate in ethanol. The later thiosemicarbazides were cyclized to substituted thiadiazoles (5,6) and triazoles (7,8) by their reaction with concentrated sulphuric acid and sodium hydroxide solution respectively. The hydrazones (9-12) were synthesised from acid hydrazides (1,2) by their reaction with substituted benzaldehyde in dioxane. The cyclization of hydrazones (9-12) with acetic anhydride gave substituted 1,3,4- oxadiazole (13-16). The structures of synthesised compounds were confirmed by IR, UV spectral data and physical means. |
| first_indexed | 2024-12-13T20:56:32Z |
| format | Article |
| id | doaj.art-9cfc0356192249dcb35f2b9756e17d39 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-13T20:56:32Z |
| publishDate | 2013-06-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-9cfc0356192249dcb35f2b9756e17d392022-12-21T23:31:44ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302013-06-01262283510.33899/edusj.2013.8981289812Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid ChloridesE. Q. MahmoodO. Th. AliK. M. DaoudAbstract<br /> The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The acid hydrazides were converted to 1- substituted thiosemicarbazides (3,4) by this reaction with ammonium thiocyanate in ethanol. The later thiosemicarbazides were cyclized to substituted thiadiazoles (5,6) and triazoles (7,8) by their reaction with concentrated sulphuric acid and sodium hydroxide solution respectively. The hydrazones (9-12) were synthesised from acid hydrazides (1,2) by their reaction with substituted benzaldehyde in dioxane. The cyclization of hydrazones (9-12) with acetic anhydride gave substituted 1,3,4- oxadiazole (13-16). The structures of synthesised compounds were confirmed by IR, UV spectral data and physical means.https://edusj.mosuljournals.com/article_89812_0e2978fbbc64a93316469d04d5d991b7.pdf1,3,4-oxadiazoles, thiadiazoles1,2,4-triazolesacid chlorides |
| spellingShingle | E. Q. Mahmood O. Th. Ali K. M. Daoud Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides مجلة التربية والعلم 1,3,4-oxadiazoles, thiadiazoles 1,2,4-triazoles acid chlorides |
| title | Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides |
| title_full | Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides |
| title_fullStr | Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides |
| title_full_unstemmed | Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides |
| title_short | Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides |
| title_sort | synthesis of some substituted 1 3 4 oxadiazoles thiadiazoles and 1 2 4 triazoles from acid chlorides |
| topic | 1,3,4-oxadiazoles, thiadiazoles 1,2,4-triazoles acid chlorides |
| url | https://edusj.mosuljournals.com/article_89812_0e2978fbbc64a93316469d04d5d991b7.pdf |
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