Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain
Abstract Aims The objective of this study was to investigate the prognostic value of urinary N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) compared with plasma NT‐proBNP in patients presenting with acute chest pain in the emergency department. Methods and results We measured simultaneously pl...
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13332 |
| _version_ | 1797976462826930176 |
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| author | Stefanie Reynen Michael Schlossbauer Ute Hubauer Julian Hupf Arno Mohr Evelyn Orso Markus Zimmermann Andreas Luchner Lars S. Maier Stefan Wallner Carsten G. Jungbauer |
| author_facet | Stefanie Reynen Michael Schlossbauer Ute Hubauer Julian Hupf Arno Mohr Evelyn Orso Markus Zimmermann Andreas Luchner Lars S. Maier Stefan Wallner Carsten G. Jungbauer |
| author_sort | Stefanie Reynen |
| collection | DOAJ |
| description | Abstract Aims The objective of this study was to investigate the prognostic value of urinary N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) compared with plasma NT‐proBNP in patients presenting with acute chest pain in the emergency department. Methods and results We measured simultaneously plasma and urinary NT‐proBNP at admission in 301 patients with acute chest pain. In our cohort, 174 patients suffered from acute coronary syndrome (ACS). A follow‐up (median of 55 months) was performed regarding the endpoints all‐cause mortality and major adverse cardiac events (mortality, congestive heart failure, ACS with the necessity of a coronary intervention, and stroke). Fifty‐four patients died during follow‐up; 98 suffered from the combined endpoint. A significant and positive correlation of urinary and plasma NT‐proBNP was found (r = 0.87, P < 0.05). Patients with troponin positive ACS had significantly elevated levels of plasma and urinary NT‐proBNP compared with those with unstable angina pectoris or chest wall syndrome (each P < 0.05). The highest levels of both biomarkers were found in patients with congestive heart failure (each P < 0.05). According to Kaplan–Meier analysis, plasma and urinary NT‐proBNP were significant predictors for mortality and the combined endpoint in the whole study cohort and in the subgroup of patients with ACS (each P < 0.05). Regarding Cox regression analysis, plasma and urinary NT‐proBNP were independent predictors for mortality and the combined endpoint (each P < 0.05). Conclusions Urinary NT‐proBNP seems to provide a significant predictive value regarding the endpoints all‐cause mortality and major adverse cardiac events in patients with acute chest pain and those with ACS. |
| first_indexed | 2024-04-11T04:51:16Z |
| format | Article |
| id | doaj.art-9cfecfac843449168b67106267e2fb8e |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-11T04:51:16Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-9cfecfac843449168b67106267e2fb8e2022-12-27T03:53:07ZengWileyESC Heart Failure2055-58222021-06-01832293230510.1002/ehf2.13332Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest painStefanie Reynen0Michael Schlossbauer1Ute Hubauer2Julian Hupf3Arno Mohr4Evelyn Orso5Markus Zimmermann6Andreas Luchner7Lars S. Maier8Stefan Wallner9Carsten G. Jungbauer10Department of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyDepartment of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyDepartment of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyEmergency Department University Hospital Regensburg Regensburg GermanyDepartment of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyDepartment of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg GermanyEmergency Department University Hospital Regensburg Regensburg GermanyDepartment of Cardiology Hospital Barmherzige Brüder Regensburg Regensburg GermanyDepartment of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyDepartment of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg GermanyDepartment of Internal Medicine II (Cardiology) University Hospital Regensburg Franz‐Josef‐Strauss‐Allee 11 Regensburg 93053 GermanyAbstract Aims The objective of this study was to investigate the prognostic value of urinary N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) compared with plasma NT‐proBNP in patients presenting with acute chest pain in the emergency department. Methods and results We measured simultaneously plasma and urinary NT‐proBNP at admission in 301 patients with acute chest pain. In our cohort, 174 patients suffered from acute coronary syndrome (ACS). A follow‐up (median of 55 months) was performed regarding the endpoints all‐cause mortality and major adverse cardiac events (mortality, congestive heart failure, ACS with the necessity of a coronary intervention, and stroke). Fifty‐four patients died during follow‐up; 98 suffered from the combined endpoint. A significant and positive correlation of urinary and plasma NT‐proBNP was found (r = 0.87, P < 0.05). Patients with troponin positive ACS had significantly elevated levels of plasma and urinary NT‐proBNP compared with those with unstable angina pectoris or chest wall syndrome (each P < 0.05). The highest levels of both biomarkers were found in patients with congestive heart failure (each P < 0.05). According to Kaplan–Meier analysis, plasma and urinary NT‐proBNP were significant predictors for mortality and the combined endpoint in the whole study cohort and in the subgroup of patients with ACS (each P < 0.05). Regarding Cox regression analysis, plasma and urinary NT‐proBNP were independent predictors for mortality and the combined endpoint (each P < 0.05). Conclusions Urinary NT‐proBNP seems to provide a significant predictive value regarding the endpoints all‐cause mortality and major adverse cardiac events in patients with acute chest pain and those with ACS.https://doi.org/10.1002/ehf2.13332Urinary NT‐proBNPAcute chest painCardiac markersNatriuretic peptides |
| spellingShingle | Stefanie Reynen Michael Schlossbauer Ute Hubauer Julian Hupf Arno Mohr Evelyn Orso Markus Zimmermann Andreas Luchner Lars S. Maier Stefan Wallner Carsten G. Jungbauer Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain ESC Heart Failure Urinary NT‐proBNP Acute chest pain Cardiac markers Natriuretic peptides |
| title | Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain |
| title_full | Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain |
| title_fullStr | Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain |
| title_full_unstemmed | Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain |
| title_short | Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain |
| title_sort | urinary n terminal pro brain natriuretic peptide prognostic value in patients with acute chest pain |
| topic | Urinary NT‐proBNP Acute chest pain Cardiac markers Natriuretic peptides |
| url | https://doi.org/10.1002/ehf2.13332 |
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