Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study
Abstract Background Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss of automated motor control and their postural instability, forcing pat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1365-8 |
| _version_ | 1818968112516562944 |
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| author | Carlijn D. J. M. Borm Mario Werkmann Femke Visser Marina Peball Diana Putz Klaus Seppi Werner Poewe Irene C. Notting Annemarie Vlaar Thomas Theelen Carel Hoyng Bastiaan R. Bloem Nienke M. de Vries |
| author_facet | Carlijn D. J. M. Borm Mario Werkmann Femke Visser Marina Peball Diana Putz Klaus Seppi Werner Poewe Irene C. Notting Annemarie Vlaar Thomas Theelen Carel Hoyng Bastiaan R. Bloem Nienke M. de Vries |
| author_sort | Carlijn D. J. M. Borm |
| collection | DOAJ |
| description | Abstract Background Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss of automated motor control and their postural instability, forcing patients to guide their movements visually. Here, we describe the study design of a cross-sectional, multi-centre study aiming to: (1) validate the Visual Impairment screening questionnaire (VIPD-Q, which aims to identify PD patients who should be referred to an ophthalmologist for further assessment); (2) study the prevalence of visual disorders in PD; (3) study the severity and clinical impact of different types of visual disorders in PD; and (4) explore treatment options for ophthalmologic disorders in PD, as a basis for future guideline development. Methods This study consists of two phases. In phase one, 750 PD patients and 250 healthy controls will be recruited to complete the VIPD-Q. In phase two, a subgroup of responders (n = 100) (with the highest and lowest scores on the VIPD-Q) will be invited for an extensive neurological and ophthalmological assessment. The in-depth ophthalmologic examination will serve as the “gold standard” for validating the VIPD-Q. Moreover, these assessments will be used to study associations between visual disorders and clinical presentation, in order to gain more insight in their clinical impact. Discussion Our study will heighten the awareness of visual problems in PD and offers a robust starting point to systematically approach this subject. In current daily practice, the association between visual problems and PD is far from obvious to both patients and clinicians. Consequently, patients may not adequately report visual problems themselves, while clinicians miss potentially treatable visual disorders. Routinely asking patients to complete a simple screening questionnaire could be an easy solution leading to timely identification of visual problems, tailored treatment, restored mobility, greater independence and improved quality of life. Trial registration Dutch Trial Registration, NL7421, Registered on 4 December 2018 – Retrospectively registered. |
| first_indexed | 2024-12-20T13:59:31Z |
| format | Article |
| id | doaj.art-9cfeed4d4e194454865f029fa107124d |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-20T13:59:31Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-9cfeed4d4e194454865f029fa107124d2022-12-21T19:38:25ZengBMCBMC Neurology1471-23772019-06-011911910.1186/s12883-019-1365-8Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional studyCarlijn D. J. M. Borm0Mario Werkmann1Femke Visser2Marina Peball3Diana Putz4Klaus Seppi5Werner Poewe6Irene C. Notting7Annemarie Vlaar8Thomas Theelen9Carel Hoyng10Bastiaan R. Bloem11Nienke M. de Vries12Department of Neurology, Parkinson Center Nijmegen (ParC) Nijmegen, Donders institute for Brain, Cognition and Behaviour, Radboud University Medical CentreDepartment of Neurology, Medical University InnsbruckDepartment of Neurology, Onze Lieve Vrouw Gasthuis (OLVG)Department of Neurology, Medical University InnsbruckDepartment of ophthalmology, Medical University InnsbruckDepartment of Neurology, Medical University InnsbruckDepartment of Neurology, Medical University InnsbruckDepartment of Ophthalmology, Leiden University Medical CentreDepartment of Neurology, Onze Lieve Vrouw Gasthuis (OLVG)Radboud University Medical Centre, Department of OphthalmologyRadboud University Medical Centre, Department of OphthalmologyDepartment of Neurology, Parkinson Center Nijmegen (ParC) Nijmegen, Donders institute for Brain, Cognition and Behaviour, Radboud University Medical CentreDepartment of Neurology, Parkinson Center Nijmegen (ParC) Nijmegen, Donders institute for Brain, Cognition and Behaviour, Radboud University Medical CentreAbstract Background Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss of automated motor control and their postural instability, forcing patients to guide their movements visually. Here, we describe the study design of a cross-sectional, multi-centre study aiming to: (1) validate the Visual Impairment screening questionnaire (VIPD-Q, which aims to identify PD patients who should be referred to an ophthalmologist for further assessment); (2) study the prevalence of visual disorders in PD; (3) study the severity and clinical impact of different types of visual disorders in PD; and (4) explore treatment options for ophthalmologic disorders in PD, as a basis for future guideline development. Methods This study consists of two phases. In phase one, 750 PD patients and 250 healthy controls will be recruited to complete the VIPD-Q. In phase two, a subgroup of responders (n = 100) (with the highest and lowest scores on the VIPD-Q) will be invited for an extensive neurological and ophthalmological assessment. The in-depth ophthalmologic examination will serve as the “gold standard” for validating the VIPD-Q. Moreover, these assessments will be used to study associations between visual disorders and clinical presentation, in order to gain more insight in their clinical impact. Discussion Our study will heighten the awareness of visual problems in PD and offers a robust starting point to systematically approach this subject. In current daily practice, the association between visual problems and PD is far from obvious to both patients and clinicians. Consequently, patients may not adequately report visual problems themselves, while clinicians miss potentially treatable visual disorders. Routinely asking patients to complete a simple screening questionnaire could be an easy solution leading to timely identification of visual problems, tailored treatment, restored mobility, greater independence and improved quality of life. Trial registration Dutch Trial Registration, NL7421, Registered on 4 December 2018 – Retrospectively registered.http://link.springer.com/article/10.1186/s12883-019-1365-8Parkinson’s diseaseOphthalmologyEyeVisual impairmentNon-motor symptomsScreening questionnaire |
| spellingShingle | Carlijn D. J. M. Borm Mario Werkmann Femke Visser Marina Peball Diana Putz Klaus Seppi Werner Poewe Irene C. Notting Annemarie Vlaar Thomas Theelen Carel Hoyng Bastiaan R. Bloem Nienke M. de Vries Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study BMC Neurology Parkinson’s disease Ophthalmology Eye Visual impairment Non-motor symptoms Screening questionnaire |
| title | Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study |
| title_full | Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study |
| title_fullStr | Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study |
| title_full_unstemmed | Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study |
| title_short | Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study |
| title_sort | towards seeing the visual impairments in parkinson s disease protocol for a multicentre observational cross sectional study |
| topic | Parkinson’s disease Ophthalmology Eye Visual impairment Non-motor symptoms Screening questionnaire |
| url | http://link.springer.com/article/10.1186/s12883-019-1365-8 |
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