Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair
The adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are unable to divide and form new myocytes in response to myocardial injury. In contrast, the developmental cardiac tissue is made up of proliferative CMs that regenerate injured myocardium. <i>In mammals</i&...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/12/1571 |
| _version_ | 1797595609703645184 |
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| author | Andrea Elia Sadia Mohsin Mohsin Khan |
| author_facet | Andrea Elia Sadia Mohsin Mohsin Khan |
| author_sort | Andrea Elia |
| collection | DOAJ |
| description | The adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are unable to divide and form new myocytes in response to myocardial injury. In contrast, the developmental cardiac tissue is made up of proliferative CMs that regenerate injured myocardium. <i>In mammals</i>, CMs during development are diploid and mononucleated. In response to cardiac maturation, CMs undergo polyploidization and binucleation associated with CM functional changes. The transition from mononucleation to binucleation coincides with unique metabolic changes and shift in energy generation. Recent studies provide evidence that metabolic reprogramming promotes CM cell cycle reentry and changes in ploidy and nucleation state in the heart that together enhances cardiac structure and function after injury. This review summarizes current literature regarding changes in CM ploidy and nucleation during development, maturation and in response to cardiac injury. Importantly, how metabolism affects CM fate transition between mononucleation and binucleation and its impact on cell cycle progression, proliferation and ability to regenerate the heart will be discussed. |
| first_indexed | 2024-03-11T02:39:01Z |
| format | Article |
| id | doaj.art-9cff0d6d6ed440c4a28b9ce7274e94d0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T02:39:01Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9cff0d6d6ed440c4a28b9ce7274e94d02023-11-18T09:42:53ZengMDPI AGCells2073-44092023-06-011212157110.3390/cells12121571Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart RepairAndrea Elia0Sadia Mohsin1Mohsin Khan2Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USACardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USACenter for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USAThe adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are unable to divide and form new myocytes in response to myocardial injury. In contrast, the developmental cardiac tissue is made up of proliferative CMs that regenerate injured myocardium. <i>In mammals</i>, CMs during development are diploid and mononucleated. In response to cardiac maturation, CMs undergo polyploidization and binucleation associated with CM functional changes. The transition from mononucleation to binucleation coincides with unique metabolic changes and shift in energy generation. Recent studies provide evidence that metabolic reprogramming promotes CM cell cycle reentry and changes in ploidy and nucleation state in the heart that together enhances cardiac structure and function after injury. This review summarizes current literature regarding changes in CM ploidy and nucleation during development, maturation and in response to cardiac injury. Importantly, how metabolism affects CM fate transition between mononucleation and binucleation and its impact on cell cycle progression, proliferation and ability to regenerate the heart will be discussed.https://www.mdpi.com/2073-4409/12/12/1571ploidycardiomyocytecell cyclemetabolismbinucleation |
| spellingShingle | Andrea Elia Sadia Mohsin Mohsin Khan Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair Cells ploidy cardiomyocyte cell cycle metabolism binucleation |
| title | Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair |
| title_full | Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair |
| title_fullStr | Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair |
| title_full_unstemmed | Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair |
| title_short | Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair |
| title_sort | cardiomyocyte ploidy metabolic reprogramming and heart repair |
| topic | ploidy cardiomyocyte cell cycle metabolism binucleation |
| url | https://www.mdpi.com/2073-4409/12/12/1571 |
| work_keys_str_mv | AT andreaelia cardiomyocyteploidymetabolicreprogrammingandheartrepair AT sadiamohsin cardiomyocyteploidymetabolicreprogrammingandheartrepair AT mohsinkhan cardiomyocyteploidymetabolicreprogrammingandheartrepair |