Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence
The first case of SARS-CoV-2 infection was reported in December 2019. Due to the rapid spread of the disease and the lack of adequate therapy, the use of plants that have a long history in the treatment of viral infections has often been considered. The aim of this paper is to provide a brief review...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1614 |
| _version_ | 1797466081708736512 |
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| author | Katarina Bijelić Maja Hitl Nebojša Kladar |
| author_facet | Katarina Bijelić Maja Hitl Nebojša Kladar |
| author_sort | Katarina Bijelić |
| collection | DOAJ |
| description | The first case of SARS-CoV-2 infection was reported in December 2019. Due to the rapid spread of the disease and the lack of adequate therapy, the use of plants that have a long history in the treatment of viral infections has often been considered. The aim of this paper is to provide a brief review of the literature on the use of phytochemicals during the new pandemic. An extensive search of published works was performed through platforms Google Scholar, PubMed, Science Direct, Web of Science and Clinicaltrials.gov. Numerous preclinical studies on the use of phytochemicals (quercetin, curcumin, baicalin, kaempferol, resveratrol, glycyrrhizin, lycorine, colchicine) against SARS-CoV-2 have shown that these components can be effective in the prevention and treatment of this infection. Clinical research has proven that the use of black cumin and green propolis as well as quercetin has positive effects. As for other phytochemicals, in addition to preclinical testing which has already been carried out, it would be necessary to conduct clinical tests in order to assert their effectiveness. For those phytochemicals whose clinical efficacy has been proven, it would be necessary to conduct research on a larger number of patients, so that the conclusions are more representative. |
| first_indexed | 2024-03-09T18:31:27Z |
| format | Article |
| id | doaj.art-9d002027b96f4d85ac1baf49395c20f9 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T18:31:27Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-9d002027b96f4d85ac1baf49395c20f92023-11-24T07:30:39ZengMDPI AGAntibiotics2079-63822022-11-011111161410.3390/antibiotics11111614Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical EvidenceKatarina Bijelić0Maja Hitl1Nebojša Kladar2Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaThe first case of SARS-CoV-2 infection was reported in December 2019. Due to the rapid spread of the disease and the lack of adequate therapy, the use of plants that have a long history in the treatment of viral infections has often been considered. The aim of this paper is to provide a brief review of the literature on the use of phytochemicals during the new pandemic. An extensive search of published works was performed through platforms Google Scholar, PubMed, Science Direct, Web of Science and Clinicaltrials.gov. Numerous preclinical studies on the use of phytochemicals (quercetin, curcumin, baicalin, kaempferol, resveratrol, glycyrrhizin, lycorine, colchicine) against SARS-CoV-2 have shown that these components can be effective in the prevention and treatment of this infection. Clinical research has proven that the use of black cumin and green propolis as well as quercetin has positive effects. As for other phytochemicals, in addition to preclinical testing which has already been carried out, it would be necessary to conduct clinical tests in order to assert their effectiveness. For those phytochemicals whose clinical efficacy has been proven, it would be necessary to conduct research on a larger number of patients, so that the conclusions are more representative.https://www.mdpi.com/2079-6382/11/11/1614phytotherapySARS-CoV-2quercetincurcuminbaicalinglycyrrhizin |
| spellingShingle | Katarina Bijelić Maja Hitl Nebojša Kladar Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence Antibiotics phytotherapy SARS-CoV-2 quercetin curcumin baicalin glycyrrhizin |
| title | Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence |
| title_full | Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence |
| title_fullStr | Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence |
| title_full_unstemmed | Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence |
| title_short | Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence |
| title_sort | phytochemicals in the prevention and treatment of sars cov 2 clinical evidence |
| topic | phytotherapy SARS-CoV-2 quercetin curcumin baicalin glycyrrhizin |
| url | https://www.mdpi.com/2079-6382/11/11/1614 |
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