Coming of Age: CD96 Emerges as Modulator of Immune Responses
CD96 represents a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD96 is expressed mainly by cells of hematopoietic origin, in particular on T and NK cells. Upon interaction with CD155 present on target cells, CD96 was found to inhibit mouse NK cells, and absence of t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01072/full |
| _version_ | 1818130327971823616 |
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| author | Hristo Georgiev Inga Ravens Georgia Papadogianni Günter Bernhardt |
| author_facet | Hristo Georgiev Inga Ravens Georgia Papadogianni Günter Bernhardt |
| author_sort | Hristo Georgiev |
| collection | DOAJ |
| description | CD96 represents a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD96 is expressed mainly by cells of hematopoietic origin, in particular on T and NK cells. Upon interaction with CD155 present on target cells, CD96 was found to inhibit mouse NK cells, and absence of this interaction either by blocking with antibody or knockout of CD96 showed profound beneficial effects in containment of tumors and metastatic spread in murine model systems. However, our knowledge regarding CD96 functions remains fragmentary. In this review, we will discuss structural features of CD96 and their putative impact on function as well as some unresolved issues such as a potential activation that may be conferred by human but not mouse CD96. This is of importance for translation into human cancer therapy. We will also address CD96 activities in the context of the immune regulatory network that consists of CD155, CD96, CD226, and TIGIT. |
| first_indexed | 2024-12-11T08:03:17Z |
| format | Article |
| id | doaj.art-9d02520a6fa7413ba4e23cacbfc62907 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T08:03:17Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9d02520a6fa7413ba4e23cacbfc629072022-12-22T01:15:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-05-01910.3389/fimmu.2018.01072369169Coming of Age: CD96 Emerges as Modulator of Immune ResponsesHristo GeorgievInga RavensGeorgia PapadogianniGünter BernhardtCD96 represents a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD96 is expressed mainly by cells of hematopoietic origin, in particular on T and NK cells. Upon interaction with CD155 present on target cells, CD96 was found to inhibit mouse NK cells, and absence of this interaction either by blocking with antibody or knockout of CD96 showed profound beneficial effects in containment of tumors and metastatic spread in murine model systems. However, our knowledge regarding CD96 functions remains fragmentary. In this review, we will discuss structural features of CD96 and their putative impact on function as well as some unresolved issues such as a potential activation that may be conferred by human but not mouse CD96. This is of importance for translation into human cancer therapy. We will also address CD96 activities in the context of the immune regulatory network that consists of CD155, CD96, CD226, and TIGIT.http://journal.frontiersin.org/article/10.3389/fimmu.2018.01072/fullCD96immunoglobulin superfamilyCD155CD226TIGITNK cells |
| spellingShingle | Hristo Georgiev Inga Ravens Georgia Papadogianni Günter Bernhardt Coming of Age: CD96 Emerges as Modulator of Immune Responses Frontiers in Immunology CD96 immunoglobulin superfamily CD155 CD226 TIGIT NK cells |
| title | Coming of Age: CD96 Emerges as Modulator of Immune Responses |
| title_full | Coming of Age: CD96 Emerges as Modulator of Immune Responses |
| title_fullStr | Coming of Age: CD96 Emerges as Modulator of Immune Responses |
| title_full_unstemmed | Coming of Age: CD96 Emerges as Modulator of Immune Responses |
| title_short | Coming of Age: CD96 Emerges as Modulator of Immune Responses |
| title_sort | coming of age cd96 emerges as modulator of immune responses |
| topic | CD96 immunoglobulin superfamily CD155 CD226 TIGIT NK cells |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.01072/full |
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