Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer

Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer

Lung cancer is one of the leading causes of cancer-related deaths in the United States. A major hurdle for improved therapies is immune suppression mediated by the tumor and its microenvironment. The lung tumor microenvironment (TME) contains large numbers of tumor-associated macrophages (TAMs), whi...

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Bibliographic Details
Main Authors: Terese Geraghty, Anugraha Rajagopalan, Rabail Aslam, Alexander Pohlman, Ishwarya Venkatesh, Andrew Zloza, David Cimbaluk, David G. DeNardo, Vineet Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
CD11b
activation
macrophages
immunotherapy
lung cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00748/full

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