Relationship between serum uric acid levels and osteoporosis
Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA) is the end product of purine metabolism in the h...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2023-10-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0040.xml |
| _version_ | 1827792112224043008 |
|---|---|
| author | Rong Xu Difei Lian Yan Xie Lin Mu Yali Wu Zhilei Chen Baoyu Zhang |
| author_facet | Rong Xu Difei Lian Yan Xie Lin Mu Yali Wu Zhilei Chen Baoyu Zhang |
| author_sort | Rong Xu |
| collection | DOAJ |
| description | Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA) is the end product of purine metabolism in the human body. Extracellular UA has antioxidant properties and is thought to have a protective effect on bone metabolism. However, the process of UA degradation can lead to intracellular oxidative stress, which together with UA-induced inflammatory factors, leads to increased bone destruction. In addition, UA can inhibit vitamin D production, resulting in secondary hyperparathyroidism and further exacerbating UA-associated bone loss. This review summarizes the relationship between serum UA levels and bone mineral density, bone turnover markers, and so on, in the hope of providing new insights into the pathogenesis and treatment of OP. |
| first_indexed | 2024-03-11T17:56:20Z |
| format | Article |
| id | doaj.art-9d0422b6d25249d7a57b51c51d608406 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-03-11T17:56:20Z |
| publishDate | 2023-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-9d0422b6d25249d7a57b51c51d6084062023-10-17T12:10:26ZengBioscientificaEndocrine Connections2049-36142023-10-01121118https://doi.org/10.1530/EC-23-0040Relationship between serum uric acid levels and osteoporosisRong Xu0Difei Lian1Yan Xie2Lin Mu3Yali Wu4Zhilei Chen5Baoyu Zhang6Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing, China Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA) is the end product of purine metabolism in the human body. Extracellular UA has antioxidant properties and is thought to have a protective effect on bone metabolism. However, the process of UA degradation can lead to intracellular oxidative stress, which together with UA-induced inflammatory factors, leads to increased bone destruction. In addition, UA can inhibit vitamin D production, resulting in secondary hyperparathyroidism and further exacerbating UA-associated bone loss. This review summarizes the relationship between serum UA levels and bone mineral density, bone turnover markers, and so on, in the hope of providing new insights into the pathogenesis and treatment of OP.https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0040.xmluric acidosteoporosishyperuricemiagoutbone metabolism |
| spellingShingle | Rong Xu Difei Lian Yan Xie Lin Mu Yali Wu Zhilei Chen Baoyu Zhang Relationship between serum uric acid levels and osteoporosis Endocrine Connections uric acid osteoporosis hyperuricemia gout bone metabolism |
| title | Relationship between serum uric acid levels and osteoporosis |
| title_full | Relationship between serum uric acid levels and osteoporosis |
| title_fullStr | Relationship between serum uric acid levels and osteoporosis |
| title_full_unstemmed | Relationship between serum uric acid levels and osteoporosis |
| title_short | Relationship between serum uric acid levels and osteoporosis |
| title_sort | relationship between serum uric acid levels and osteoporosis |
| topic | uric acid osteoporosis hyperuricemia gout bone metabolism |
| url | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0040.xml |
| work_keys_str_mv | AT rongxu relationshipbetweenserumuricacidlevelsandosteoporosis AT difeilian relationshipbetweenserumuricacidlevelsandosteoporosis AT yanxie relationshipbetweenserumuricacidlevelsandosteoporosis AT linmu relationshipbetweenserumuricacidlevelsandosteoporosis AT yaliwu relationshipbetweenserumuricacidlevelsandosteoporosis AT zhileichen relationshipbetweenserumuricacidlevelsandosteoporosis AT baoyuzhang relationshipbetweenserumuricacidlevelsandosteoporosis |