Induction of Stearoyl-CoA 9-Desaturase 1 Protects Human Mesenchymal Stromal Cells Against Palmitic Acid-Induced Lipotoxicity and Inflammation

Induction of Stearoyl-CoA 9-Desaturase 1 Protects Human Mesenchymal Stromal Cells Against Palmitic Acid-Induced Lipotoxicity and Inflammation

In bone diseases such as osteonecrosis and osteoporosis, a shift toward a preferential differentiation of mesenchymal stromal cells (MSC) into adipocytes at the expense of the osteoblastic lineage is described, leading to excessive accumulation of adipocytes in the bone marrow of the patients. The i...

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Bibliographic Details
Main Authors: Antoine Dalla Valle, Pascale Vertongen, Delphine Spruyt, Jessica Lechanteur, Valérie Suain, Nathalie Gaspard, Jean-Pierre Brion, Valérie Gangji, Joanne Rasschaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Endocrinology
Subjects:
human mesenchymal stromal cells (hMSC)
fatty acids
lipotoxicity
endoplasmic reticulum stress (ER stress)
inflammation
liver X receptor activator
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00726/full

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