Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

The triggers of late-onset sporadic Alzheimer’s disease (AD) are still poorly understood. Impairment of protein phosphorylation with age is well-known; however, the role of the phosphorylation in β-amyloid peptide (Aβ) is not studied sufficiently. Zinc-induced oligomerization of Aβ represents a pote...

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Bibliographic Details
Main Authors: Evgeny P. Barykin, Irina Y. Petrushanko, Sergey A. Kozin, Georgy B. Telegin, Alexander S. Chernov, Olga D. Lopina, Sergey P. Radko, Vladimir A. Mitkevich, Alexander A. Makarov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
β-amyloid
Na+
K+-ATPase
zinc
protein phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00302/full

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