STING Agonists as Cancer Therapeutics

STING Agonists as Cancer Therapeutics

The interrogation of intrinsic and adaptive resistance to cancer immunotherapy has identified lack of antigen presentation and type I interferon signaling as biomarkers of non-T-cell-inflamed tumors and clinical progression. A myriad of pre-clinical studies have implicated the cGAS/stimulator of int...

Full description

Bibliographic Details
Main Authors:	Afsaneh Amouzegar, Manoj Chelvanambi, Jessica N. Filderman, Walter J. Storkus, Jason J. Luke
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Cancers
Subjects:	stimulator of interferon genes cGAS STING agonist type I interferon tumor vasculature anti-tumor immunity
Online Access:	https://www.mdpi.com/2072-6694/13/11/2695

Similar Items

cGAS‐STING signaling in cancer: Regulation and therapeutic targeting
by: Xinzou Fan, et al.
Published: (2023-09-01)

The Chicken cGAS–STING Pathway Exerts Interferon-Independent Antiviral Function via Cell Apoptosis
by: Sen Jiang, et al.
Published: (2023-08-01)

Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
by: Xi Chen, et al.
Published: (2024-01-01)

Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release
by: Lei Xu, et al.
Published: (2022-06-01)

Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
by: Jiawen Zhang, et al.
Published: (2024-01-01)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
by: Nengwen Xia, et al.
Published: (2022-10-01)

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
by: Yige Huang, et al.
Published: (2023-11-01)

STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments
by: Danilo Guerini
Published: (2022-03-01)

Interferons and interferon-related pathways in heart disease
by: Duc Tin Tran, et al.
Published: (2024-04-01)

At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment
by: Tatyana V. Korneenko, et al.
Published: (2023-12-01)

Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy
by: Kewang Luo, et al.
Published: (2022-07-01)

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy
by: Leila Motedayen Aval, et al.
Published: (2020-10-01)

Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift
by: Matilde Monti, et al.
Published: (2024-01-01)

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus
by: Wen-Yu Cheng, et al.
Published: (2018-06-01)

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics
by: Tangxin Zhang, et al.
Published: (2023-04-01)

Commentary: Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
by: Cali M. McEntee, et al.
Published: (2022-06-01)

cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma [version 1; peer review: 3 approved]
by: Amy B Heimberger, et al.
Published: (2022-09-01)

Updated roles of cGAS-STING signaling in autoimmune diseases
by: Ya Liu, et al.
Published: (2023-09-01)

Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections
by: Dongdong Xu, et al.
Published: (2024-05-01)

Cancer immunotherapy strategies that target the cGAS-STING pathway
by: Zhuoying Tian, et al.
Published: (2022-10-01)

Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer
by: Jelena Viculin, et al.
Published: (2023-07-01)

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon-β activation
by: Brian T. Reiss, et al.
Published: (2023-12-01)

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models
by: Leila Takahashi-Ruiz, et al.
Published: (2022-12-01)

The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process
by: Bárbara Andrade, et al.
Published: (2022-12-01)

The cGAS/STING/IFN-1 Response in Squamous Head and Neck Cancer Cells after Genotoxic Challenges and Abrogation of the ATR-Chk1 and Fanconi Anemia Axis
by: Sebastian Zahnreich, et al.
Published: (2023-10-01)

STING as an emerging therapeutic target for drug discovery: Perspectives from the global patent landscape
by: Xiangjun Kong, et al.
Published: (2023-02-01)

Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation
by: Yang Yu, et al.
Published: (2022-09-01)

Novel Auger-Electron-Emitting <sup>191</sup>Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma
by: Honoka Obata, et al.
Published: (2023-10-01)

The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer
by: Quinn Storozynsky, et al.
Published: (2020-11-01)

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes
by: Lise Lauterbach-Rivière, et al.
Published: (2020-05-01)

Discovery of Novel STING Inhibitors Based on the Structure of the Mouse STING Agonist DMXAA
by: Jiajia Chang, et al.
Published: (2023-03-01)

Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
by: Chunsheng Yang, et al.
Published: (2023-09-01)

Microtubule-destabilizing agents enhance STING-mediated innate immune response via biased mechanism in human monocyte cells
by: Songhyun Lim, et al.
Published: (2023-12-01)

Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
by: Jincai Wen, et al.
Published: (2023-12-01)

Type-I Interferon Signaling in Fanconi Anemia
by: Karima Landelouci, et al.
Published: (2022-02-01)

Bovine delta papillomavirus E5 oncoprotein negatively regulates the cGAS-STING signaling pathway in cattle in a spontaneous model of viral disease
by: Francesca De Falco, et al.
Published: (2022-10-01)

Development of Small-Molecule STING Activators for Cancer Immunotherapy
by: Hee Ra Jung, et al.
Published: (2021-12-01)

A novel STING agonist with systemic and durable anti‐tumour activity
by: Xiyuan Wang, et al.
Published: (2023-10-01)

cGAS–STING, an important signaling pathway in diseases and their therapy
by: Qijie Li, et al.
Published: (2024-04-01)

A Thermosensitive Bi‐Adjuvant Hydrogel Triggers Epitope Spreading to Promote the Anti‐Tumor Efficacy of Frameshift Neoantigens
by: Yaohua Ke, et al.
Published: (2024-04-01)