Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)
Abstract Background The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the as...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13058-018-1077-9 |
| _version_ | 1818960426865524736 |
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| author | Jennifer M. Mongiovi Gary R. Zirpoli Rikki Cannioto Lara E. Sucheston-Campbell Dawn L. Hershman Joseph M. Unger Halle C. F. Moore James A. Stewart Claudine Isaacs Timothy J. Hobday Muhammad Salim Gabriel N. Hortobagyi Julie R. Gralow G. Thomas Budd Kathy S. Albain Christine B. Ambrosone Susan E. McCann |
| author_facet | Jennifer M. Mongiovi Gary R. Zirpoli Rikki Cannioto Lara E. Sucheston-Campbell Dawn L. Hershman Joseph M. Unger Halle C. F. Moore James A. Stewart Claudine Isaacs Timothy J. Hobday Muhammad Salim Gabriel N. Hortobagyi Julie R. Gralow G. Thomas Budd Kathy S. Albain Christine B. Ambrosone Susan E. McCann |
| author_sort | Jennifer M. Mongiovi |
| collection | DOAJ |
| description | Abstract Background The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10–30%, > 30%) (n = 900). Results The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66–0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01–1.40, p = 0.05). Conclusions Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018. |
| first_indexed | 2024-12-20T11:57:21Z |
| format | Article |
| id | doaj.art-9d0a7a1284e54998b733c15ed2ca4e29 |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-12-20T11:57:21Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-9d0a7a1284e54998b733c15ed2ca4e292022-12-21T19:41:37ZengBMCBreast Cancer Research1465-542X2018-11-0120111210.1186/s13058-018-1077-9Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)Jennifer M. Mongiovi0Gary R. Zirpoli1Rikki Cannioto2Lara E. Sucheston-Campbell3Dawn L. Hershman4Joseph M. Unger5Halle C. F. Moore6James A. Stewart7Claudine Isaacs8Timothy J. Hobday9Muhammad Salim10Gabriel N. Hortobagyi11Julie R. Gralow12G. Thomas Budd13Kathy S. Albain14Christine B. Ambrosone15Susan E. McCann16University at BuffaloBoston UniversityRoswell Park Cancer InstituteThe Ohio State UniversityColumbia UniversitySWOG Statistical Center, Fred Hutchinson Cancer Research CenterCleveland ClinicBaystate Medical CenterGeorgetown UniversityMayo ClinicAllan Blair Cancer CentreThe University of Texas MD Anderson Cancer CenterSeattle Cancer Care AllianceCleveland ClinicLoyola University Chicago Stritch School of MedicineRoswell Park Cancer InstituteRoswell Park Cancer InstituteAbstract Background The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10–30%, > 30%) (n = 900). Results The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66–0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01–1.40, p = 0.05). Conclusions Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.http://link.springer.com/article/10.1186/s13058-018-1077-9Chemotherapy-induced peripheral neuropathyBreast cancerDietTaxanePeripheral nervous system diseases |
| spellingShingle | Jennifer M. Mongiovi Gary R. Zirpoli Rikki Cannioto Lara E. Sucheston-Campbell Dawn L. Hershman Joseph M. Unger Halle C. F. Moore James A. Stewart Claudine Isaacs Timothy J. Hobday Muhammad Salim Gabriel N. Hortobagyi Julie R. Gralow G. Thomas Budd Kathy S. Albain Christine B. Ambrosone Susan E. McCann Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) Breast Cancer Research Chemotherapy-induced peripheral neuropathy Breast cancer Diet Taxane Peripheral nervous system diseases |
| title | Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) |
| title_full | Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) |
| title_fullStr | Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) |
| title_full_unstemmed | Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) |
| title_short | Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221) |
| title_sort | associations between self reported diet during treatment and chemotherapy induced peripheral neuropathy in a cooperative group trial s0221 |
| topic | Chemotherapy-induced peripheral neuropathy Breast cancer Diet Taxane Peripheral nervous system diseases |
| url | http://link.springer.com/article/10.1186/s13058-018-1077-9 |
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