Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer
Abstract Background Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer stem cell marker for indicating tumour progression. However, the progno...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07070-2 |
| _version_ | 1818081826795683840 |
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| author | Yu Song Bin Zhao Yali Xu Xinyu Ren Yan Lin Liangrui Zhou Qiang Sun |
| author_facet | Yu Song Bin Zhao Yali Xu Xinyu Ren Yan Lin Liangrui Zhou Qiang Sun |
| author_sort | Yu Song |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer stem cell marker for indicating tumour progression. However, the prognostic significance of these two markers remains to be verified. This study was conducted to investigate the correlation between BCAT1 and CD133 expression and clinicopathological features, as well as the prognosis of patients with TNBC. Methods The study cohort included 291 patients with TNBC. Tissue microarrays were constructed for both cancer and normal tissues. The expression of BCAT1 and CD133 was detected by immunohistochemical staining, and the levels were evaluated using an H-scoring system. Cut-off points for BCAT1 and CD133 expression were determined using receiver operating characteristic curves. Results The median follow-up time for the study participants was 68.73 months (range: 1.37–103.6 months). The 5-year disease-free survival (DFS) and overall survival (OS) rates of the 291 patients with TNBC were 72.51 and 82.47%, respectively. Higher levels of BCAT1 and CD133 expression independently indicated shorter DFS and OS. High levels of both BCAT1 and CD133 expression were detected in 36 (12.37%) patients, who had significantly shorter DFS and OS (both P < 0.001) compared to other patients. Conclusion BCAT1 and CD133 can be considered as biomarkers with prognostic significance for TNBC. |
| first_indexed | 2024-12-10T19:12:23Z |
| format | Article |
| id | doaj.art-9d0a91d0d5384e54ac7ca556a0b2969a |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-10T19:12:23Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9d0a91d0d5384e54ac7ca556a0b2969a2022-12-22T01:36:42ZengBMCBMC Cancer1471-24072020-06-0120111710.1186/s12885-020-07070-2Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancerYu Song0Bin Zhao1Yali Xu2Xinyu Ren3Yan Lin4Liangrui Zhou5Qiang Sun6Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background Previous studies have shown that branched-chain amino acid transferase 1 (BCAT1) is associated with tumour progression in triple-negative breast cancer (TNBC). Furthermore, CD133 has emerged as a novel cancer stem cell marker for indicating tumour progression. However, the prognostic significance of these two markers remains to be verified. This study was conducted to investigate the correlation between BCAT1 and CD133 expression and clinicopathological features, as well as the prognosis of patients with TNBC. Methods The study cohort included 291 patients with TNBC. Tissue microarrays were constructed for both cancer and normal tissues. The expression of BCAT1 and CD133 was detected by immunohistochemical staining, and the levels were evaluated using an H-scoring system. Cut-off points for BCAT1 and CD133 expression were determined using receiver operating characteristic curves. Results The median follow-up time for the study participants was 68.73 months (range: 1.37–103.6 months). The 5-year disease-free survival (DFS) and overall survival (OS) rates of the 291 patients with TNBC were 72.51 and 82.47%, respectively. Higher levels of BCAT1 and CD133 expression independently indicated shorter DFS and OS. High levels of both BCAT1 and CD133 expression were detected in 36 (12.37%) patients, who had significantly shorter DFS and OS (both P < 0.001) compared to other patients. Conclusion BCAT1 and CD133 can be considered as biomarkers with prognostic significance for TNBC.http://link.springer.com/article/10.1186/s12885-020-07070-2Triple-negative breast cancerBCAT1CD133PrognosisBiomarker |
| spellingShingle | Yu Song Bin Zhao Yali Xu Xinyu Ren Yan Lin Liangrui Zhou Qiang Sun Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer BMC Cancer Triple-negative breast cancer BCAT1 CD133 Prognosis Biomarker |
| title | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer |
| title_full | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer |
| title_fullStr | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer |
| title_full_unstemmed | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer |
| title_short | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer |
| title_sort | prognostic significance of branched chain amino acid transferase 1 and cd133 in triple negative breast cancer |
| topic | Triple-negative breast cancer BCAT1 CD133 Prognosis Biomarker |
| url | http://link.springer.com/article/10.1186/s12885-020-07070-2 |
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