Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study
Introduction: Brain lesions can be caused by varied etiological factors like neoplastic, infectious, inflammatory and vascular diseases. Accurate diagnosis in very important for correct neurosurgical treatment. A retrospective histopathological study of brain lesions is of utmost importance because...
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JCDR Research and Publications Private Limited
2022-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/17237/60688_CE(AD)_F(IS)_PF1(SC_KM)_PFA(SS)_PB(SC_SS)_PN(SS).pdf |
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| author | Vijaya Lakshmi Muram Reddy Sunanda Lakshmi Gelli venkata Durga Kharidehal Penchala Reddy Muram Reddy Mohan Rao Nandam Syamsundara Rao Byna Bhavana Grandhi |
| author_facet | Vijaya Lakshmi Muram Reddy Sunanda Lakshmi Gelli venkata Durga Kharidehal Penchala Reddy Muram Reddy Mohan Rao Nandam Syamsundara Rao Byna Bhavana Grandhi |
| author_sort | Vijaya Lakshmi Muram Reddy |
| collection | DOAJ |
| description | Introduction: Brain lesions can be caused by varied etiological factors like neoplastic, infectious, inflammatory and vascular diseases. Accurate diagnosis in very important for correct neurosurgical treatment. A retrospective histopathological study of brain lesions is of utmost importance because as it can demonstrate the changes in the spectrum of brain lesions, burden of disease in the community, can reveal the possible risk factors and can suggest probable treatment methods for various neoplastic and non neoplastic brain lesions.
Aim: To evaluate the incidence, age distribution, gender distribution, and histopathological spectrum of neoplastic and non neoplastic lesions of brain.
Materials and Methods: This retrospective observational study was conducted in the Department of Pathology at Narayana Medical College, Nellore, Andhra Pradesh, India, from January 2019 to December 2021. Total 216 cases were studied. The tumours were classified under World Health Organisation (WHO) classification. To test the mean difference between the groups, Independent sample t-test was done. Results: Out of 216 cases, 180 (83%) were neoplastic and 36 (17%) were non neoplastic lesions. The male:female ratio was 1.03:1. Non neoplastic lesions were common in males (22, 61.11%), while neoplastic lesions were common in females (92, 51.11%). The most common age group affected was 41-50 years (55, 25.46%). Astrocytoma (41, 22.77%) followed by meningioma (40, 22.22%) were the common neoplastic tumours and haematoma (7, 19.44%) was the most common non neoplastic lesion in adults. Common tumour in children (<18 years) was diffuse fibrillary astrocytoma (3/11, 27.27%) and chronic inflammatory pathology was the common non neoplastic lesion (2/11, 18.18%).
Conclusion: Majority of cases were seen in 41-50 years age group. Astrocytoma was the common neoplastic tumour and haematoma was the common non neoplastic lesion in adults. Diffuse fibrillary astrocytoma was the common tumour and chronic inflammatory pathology was the common non neoplastic lesion in children. |
| first_indexed | 2024-04-10T21:10:05Z |
| format | Article |
| id | doaj.art-9d0ca5cf08074b7eade0a2b66c7a741a |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T21:10:05Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-9d0ca5cf08074b7eade0a2b66c7a741a2023-01-21T03:53:56ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-12-011612EC10EC1410.7860/JCDR/2022/60688.17237Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational StudyVijaya Lakshmi Muram Reddy0Sunanda Lakshmi Gelli venkata1Durga Kharidehal2Penchala Reddy Muram Reddy3Mohan Rao Nandam4Syamsundara Rao Byna5Bhavana Grandhi6Associate Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Assistant Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Professor and Head, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Associate Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India.Introduction: Brain lesions can be caused by varied etiological factors like neoplastic, infectious, inflammatory and vascular diseases. Accurate diagnosis in very important for correct neurosurgical treatment. A retrospective histopathological study of brain lesions is of utmost importance because as it can demonstrate the changes in the spectrum of brain lesions, burden of disease in the community, can reveal the possible risk factors and can suggest probable treatment methods for various neoplastic and non neoplastic brain lesions. Aim: To evaluate the incidence, age distribution, gender distribution, and histopathological spectrum of neoplastic and non neoplastic lesions of brain. Materials and Methods: This retrospective observational study was conducted in the Department of Pathology at Narayana Medical College, Nellore, Andhra Pradesh, India, from January 2019 to December 2021. Total 216 cases were studied. The tumours were classified under World Health Organisation (WHO) classification. To test the mean difference between the groups, Independent sample t-test was done. Results: Out of 216 cases, 180 (83%) were neoplastic and 36 (17%) were non neoplastic lesions. The male:female ratio was 1.03:1. Non neoplastic lesions were common in males (22, 61.11%), while neoplastic lesions were common in females (92, 51.11%). The most common age group affected was 41-50 years (55, 25.46%). Astrocytoma (41, 22.77%) followed by meningioma (40, 22.22%) were the common neoplastic tumours and haematoma (7, 19.44%) was the most common non neoplastic lesion in adults. Common tumour in children (<18 years) was diffuse fibrillary astrocytoma (3/11, 27.27%) and chronic inflammatory pathology was the common non neoplastic lesion (2/11, 18.18%). Conclusion: Majority of cases were seen in 41-50 years age group. Astrocytoma was the common neoplastic tumour and haematoma was the common non neoplastic lesion in adults. Diffuse fibrillary astrocytoma was the common tumour and chronic inflammatory pathology was the common non neoplastic lesion in children.https://www.jcdr.net/articles/PDF/17237/60688_CE(AD)_F(IS)_PF1(SC_KM)_PFA(SS)_PB(SC_SS)_PN(SS).pdfadultsastrocytomachildrenhaematoma |
| spellingShingle | Vijaya Lakshmi Muram Reddy Sunanda Lakshmi Gelli venkata Durga Kharidehal Penchala Reddy Muram Reddy Mohan Rao Nandam Syamsundara Rao Byna Bhavana Grandhi Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study Journal of Clinical and Diagnostic Research adults astrocytoma children haematoma |
| title | Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study |
| title_full | Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study |
| title_fullStr | Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study |
| title_full_unstemmed | Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study |
| title_short | Histopathological Spectrum of Neoplastic and Non Neoplastic Brain Lesions at a Tertiary Care Centre in South India- A Retrospective Observational Study |
| title_sort | histopathological spectrum of neoplastic and non neoplastic brain lesions at a tertiary care centre in south india a retrospective observational study |
| topic | adults astrocytoma children haematoma |
| url | https://www.jcdr.net/articles/PDF/17237/60688_CE(AD)_F(IS)_PF1(SC_KM)_PFA(SS)_PB(SC_SS)_PN(SS).pdf |
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