Iron Metabolism in Ferroptosis
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.590226/full |
| _version_ | 1828446610905890816 |
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| author | Xin Chen Xin Chen Chunhua Yu Rui Kang Daolin Tang Daolin Tang |
| author_facet | Xin Chen Xin Chen Chunhua Yu Rui Kang Daolin Tang Daolin Tang |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly controlled by regulators involved in many aspects of iron metabolism, such as iron uptake, storage, utilization, and efflux. Translational and transcriptional regulation of iron homeostasis provide an integrated network to determine the sensitivity of ferroptosis. Impaired ferroptosis is implicated in various iron-related pathological conditions or diseases, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. Understanding the molecular mechanisms underlying the regulation of iron metabolism during ferroptosis may provide effective strategies for the treatment of ferroptosis-associated diseases. Indeed, iron chelators effectively prevent the occurrence of ferroptosis, which may provide new approaches for the treatment of iron-related disorders. In this review, we summarize recent advances in the theoretical modeling of iron-dependent ferroptosis, and highlight the therapeutic implications of iron chelators in diseases. |
| first_indexed | 2024-12-10T22:15:42Z |
| format | Article |
| id | doaj.art-9d0dc68241c849159ab5b7323687faad |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-10T22:15:42Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9d0dc68241c849159ab5b7323687faad2022-12-22T01:31:29ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-10-01810.3389/fcell.2020.590226590226Iron Metabolism in FerroptosisXin Chen0Xin Chen1Chunhua Yu2Rui Kang3Daolin Tang4Daolin Tang5Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesFerroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly controlled by regulators involved in many aspects of iron metabolism, such as iron uptake, storage, utilization, and efflux. Translational and transcriptional regulation of iron homeostasis provide an integrated network to determine the sensitivity of ferroptosis. Impaired ferroptosis is implicated in various iron-related pathological conditions or diseases, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. Understanding the molecular mechanisms underlying the regulation of iron metabolism during ferroptosis may provide effective strategies for the treatment of ferroptosis-associated diseases. Indeed, iron chelators effectively prevent the occurrence of ferroptosis, which may provide new approaches for the treatment of iron-related disorders. In this review, we summarize recent advances in the theoretical modeling of iron-dependent ferroptosis, and highlight the therapeutic implications of iron chelators in diseases.https://www.frontiersin.org/article/10.3389/fcell.2020.590226/fullferroptosiscell deathironlipid perioxidationdisease |
| spellingShingle | Xin Chen Xin Chen Chunhua Yu Rui Kang Daolin Tang Daolin Tang Iron Metabolism in Ferroptosis Frontiers in Cell and Developmental Biology ferroptosis cell death iron lipid perioxidation disease |
| title | Iron Metabolism in Ferroptosis |
| title_full | Iron Metabolism in Ferroptosis |
| title_fullStr | Iron Metabolism in Ferroptosis |
| title_full_unstemmed | Iron Metabolism in Ferroptosis |
| title_short | Iron Metabolism in Ferroptosis |
| title_sort | iron metabolism in ferroptosis |
| topic | ferroptosis cell death iron lipid perioxidation disease |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.590226/full |
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