Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.

Bibliographic Details
Main Authors: Zhiqiang Wang, Chunxiao Zhang, Charles David Warden, Zheng Liu, Yate-Ching Yuan, Chao Guo, Charles Wang, Jinhui Wang, Xiwei Wu, Richard Ermel, Steven L. Vonderfecht, Xiuli Wang, Christine Brown, Stephen Forman, Yaling Yang, M. James You, WenYong Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03340-w
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author Zhiqiang Wang
Chunxiao Zhang
Charles David Warden
Zheng Liu
Yate-Ching Yuan
Chao Guo
Charles Wang
Jinhui Wang
Xiwei Wu
Richard Ermel
Steven L. Vonderfecht
Xiuli Wang
Christine Brown
Stephen Forman
Yaling Yang
M. James You
WenYong Chen
author_facet Zhiqiang Wang
Chunxiao Zhang
Charles David Warden
Zheng Liu
Yate-Ching Yuan
Chao Guo
Charles Wang
Jinhui Wang
Xiwei Wu
Richard Ermel
Steven L. Vonderfecht
Xiuli Wang
Christine Brown
Stephen Forman
Yaling Yang
M. James You
WenYong Chen
author_sort Zhiqiang Wang
collection DOAJ
description Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.
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spelling doaj.art-9d0e1dc32e3944ccbb5ec887342c8d2e2022-12-22T00:14:24ZengNature PortfolioCommunications Biology2399-36422022-04-015111510.1038/s42003-022-03340-wLoss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemiaZhiqiang Wang0Chunxiao Zhang1Charles David Warden2Zheng Liu3Yate-Ching Yuan4Chao Guo5Charles Wang6Jinhui Wang7Xiwei Wu8Richard Ermel9Steven L. Vonderfecht10Xiuli Wang11Christine Brown12Stephen Forman13Yaling Yang14M. James You15WenYong Chen16Department of Cancer Biology, Beckman Research Institute, City of HopeDepartment of Cancer Biology, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeCenter for Comparative Medicine, Beckman Research Institute, City of HopeConsultant in Veterinary PathologyDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Beckman Research Institute, City of HopeStudies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.https://doi.org/10.1038/s42003-022-03340-w
spellingShingle Zhiqiang Wang
Chunxiao Zhang
Charles David Warden
Zheng Liu
Yate-Ching Yuan
Chao Guo
Charles Wang
Jinhui Wang
Xiwei Wu
Richard Ermel
Steven L. Vonderfecht
Xiuli Wang
Christine Brown
Stephen Forman
Yaling Yang
M. James You
WenYong Chen
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
Communications Biology
title Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
title_full Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
title_fullStr Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
title_full_unstemmed Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
title_short Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
title_sort loss of sirt1 inhibits hematopoietic stem cell aging and age dependent mixed phenotype acute leukemia
url https://doi.org/10.1038/s42003-022-03340-w
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