Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-04-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-022-03340-w |
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author | Zhiqiang Wang Chunxiao Zhang Charles David Warden Zheng Liu Yate-Ching Yuan Chao Guo Charles Wang Jinhui Wang Xiwei Wu Richard Ermel Steven L. Vonderfecht Xiuli Wang Christine Brown Stephen Forman Yaling Yang M. James You WenYong Chen |
author_facet | Zhiqiang Wang Chunxiao Zhang Charles David Warden Zheng Liu Yate-Ching Yuan Chao Guo Charles Wang Jinhui Wang Xiwei Wu Richard Ermel Steven L. Vonderfecht Xiuli Wang Christine Brown Stephen Forman Yaling Yang M. James You WenYong Chen |
author_sort | Zhiqiang Wang |
collection | DOAJ |
description | Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia. |
first_indexed | 2024-12-12T19:32:09Z |
format | Article |
id | doaj.art-9d0e1dc32e3944ccbb5ec887342c8d2e |
institution | Directory Open Access Journal |
issn | 2399-3642 |
language | English |
last_indexed | 2024-12-12T19:32:09Z |
publishDate | 2022-04-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Communications Biology |
spelling | doaj.art-9d0e1dc32e3944ccbb5ec887342c8d2e2022-12-22T00:14:24ZengNature PortfolioCommunications Biology2399-36422022-04-015111510.1038/s42003-022-03340-wLoss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemiaZhiqiang Wang0Chunxiao Zhang1Charles David Warden2Zheng Liu3Yate-Ching Yuan4Chao Guo5Charles Wang6Jinhui Wang7Xiwei Wu8Richard Ermel9Steven L. Vonderfecht10Xiuli Wang11Christine Brown12Stephen Forman13Yaling Yang14M. James You15WenYong Chen16Department of Cancer Biology, Beckman Research Institute, City of HopeDepartment of Cancer Biology, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeDepartment of Molecular Medicine, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeIntegrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of HopeCenter for Comparative Medicine, Beckman Research Institute, City of HopeConsultant in Veterinary PathologyDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Beckman Research Institute, City of HopeStudies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.https://doi.org/10.1038/s42003-022-03340-w |
spellingShingle | Zhiqiang Wang Chunxiao Zhang Charles David Warden Zheng Liu Yate-Ching Yuan Chao Guo Charles Wang Jinhui Wang Xiwei Wu Richard Ermel Steven L. Vonderfecht Xiuli Wang Christine Brown Stephen Forman Yaling Yang M. James You WenYong Chen Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia Communications Biology |
title | Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia |
title_full | Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia |
title_fullStr | Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia |
title_full_unstemmed | Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia |
title_short | Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia |
title_sort | loss of sirt1 inhibits hematopoietic stem cell aging and age dependent mixed phenotype acute leukemia |
url | https://doi.org/10.1038/s42003-022-03340-w |
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