Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.

Bibliographic Details
Main Authors: Zhiqiang Wang, Chunxiao Zhang, Charles David Warden, Zheng Liu, Yate-Ching Yuan, Chao Guo, Charles Wang, Jinhui Wang, Xiwei Wu, Richard Ermel, Steven L. Vonderfecht, Xiuli Wang, Christine Brown, Stephen Forman, Yaling Yang, M. James You, WenYong Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03340-w

Internet

https://doi.org/10.1038/s42003-022-03340-w

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