Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature
Abstract Background Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematolo...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-03753-z |
| _version_ | 1811171711615238144 |
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| author | Abolghasem Allahyari Amirhosein Maharati Amir Masoud Jafari-Nozad Alireza zangooie |
| author_facet | Abolghasem Allahyari Amirhosein Maharati Amir Masoud Jafari-Nozad Alireza zangooie |
| author_sort | Abolghasem Allahyari |
| collection | DOAJ |
| description | Abstract Background Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage. The coexistence of CML and MM that is a rare phenomenon, with only 29 cases reported in the literature. To the best of our, this combination of triple primary cancers has not been reported in a single patient. Case presentation Herein, we reported a case of an 85-year-old Iranian male with three confirmed primary malignant neoplasms. The patient presented with synchronous prostate cancer and CML, in august 2016. He received imatinib and nilotinib for CML and hormonal therapy for prostate cancer. He remained in good control at further follow-ups for about 5 years. In the follow-up period and after 61 months treatment with tyrosine kinase inhibitors (TKIs), CML was undetectable in molecular tests, but the presence of serum M-protein, abnormal plasma cells in the bone marrow, and CRAB criteria was compatible with MM. Conclusion We must evaluate the possibility of multiple primary cancers during cancer treatment and follow-up and it may be worthwhile to monitor serum electrophoresis and protein levels in TKIs-treated patients. |
| first_indexed | 2024-04-10T17:18:34Z |
| format | Article |
| id | doaj.art-9d10451d0ea543d8a2d95659b65da845 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-10T17:18:34Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-9d10451d0ea543d8a2d95659b65da8452023-02-05T12:14:04ZengBMCJournal of Medical Case Reports1752-19472023-02-011711610.1186/s13256-023-03753-zProstate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literatureAbolghasem Allahyari0Amirhosein Maharati1Amir Masoud Jafari-Nozad2Alireza zangooie3Department of Hematology-Oncology, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Mashhad University of Medical SciencesStudent Research Committee, Birjand University of Medical SciencesStudent Research Committee, Birjand University of Medical SciencesAbstract Background Synchronous or metachronous multiple primary malignancies (MPMs) are a known phenomenon. These occurrences may be spontaneous or related to environmental risk factors or genetic predisposition. Chronic myelogenous leukemia (CML) and Multiple myeloma (MM) are two uncommon hematologic malignancies, arises from two different cell lineage. The coexistence of CML and MM that is a rare phenomenon, with only 29 cases reported in the literature. To the best of our, this combination of triple primary cancers has not been reported in a single patient. Case presentation Herein, we reported a case of an 85-year-old Iranian male with three confirmed primary malignant neoplasms. The patient presented with synchronous prostate cancer and CML, in august 2016. He received imatinib and nilotinib for CML and hormonal therapy for prostate cancer. He remained in good control at further follow-ups for about 5 years. In the follow-up period and after 61 months treatment with tyrosine kinase inhibitors (TKIs), CML was undetectable in molecular tests, but the presence of serum M-protein, abnormal plasma cells in the bone marrow, and CRAB criteria was compatible with MM. Conclusion We must evaluate the possibility of multiple primary cancers during cancer treatment and follow-up and it may be worthwhile to monitor serum electrophoresis and protein levels in TKIs-treated patients.https://doi.org/10.1186/s13256-023-03753-zTriple primary cancerProstate cancerChronic myelogenous leukemiaMultiple myelomaCase report |
| spellingShingle | Abolghasem Allahyari Amirhosein Maharati Amir Masoud Jafari-Nozad Alireza zangooie Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature Journal of Medical Case Reports Triple primary cancer Prostate cancer Chronic myelogenous leukemia Multiple myeloma Case report |
| title | Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature |
| title_full | Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature |
| title_fullStr | Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature |
| title_full_unstemmed | Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature |
| title_short | Prostate cancer, chronic myelogenous leukemia and multiple myeloma in a single patient: a case report and review of the literature |
| title_sort | prostate cancer chronic myelogenous leukemia and multiple myeloma in a single patient a case report and review of the literature |
| topic | Triple primary cancer Prostate cancer Chronic myelogenous leukemia Multiple myeloma Case report |
| url | https://doi.org/10.1186/s13256-023-03753-z |
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