Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease
Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the format...
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Ss.Cyril and Methodius University, Skopje
2023-03-01
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| Series: | Macedonian Veterinary Review |
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| Online Access: | https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2023_0014 |
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| author | Hande Sağoğlu Remzi Gönül Lora Koenhemsi Emine Merve Alan Suzan Murat Ashkan Seddigh Nia Mehmet Erman Or |
| author_facet | Hande Sağoğlu Remzi Gönül Lora Koenhemsi Emine Merve Alan Suzan Murat Ashkan Seddigh Nia Mehmet Erman Or |
| author_sort | Hande Sağoğlu |
| collection | DOAJ |
| description | Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the formation of fatal arrhythmias such as torsades de pointes. A fast and accurate assessment is therefore essential. The study aimed to examine the changes in QT duration in MMVD cases of CKCS and to calculate the corrected QT durations with Bazett’s formula in various stages of the disease. The study included 20 CKCS dogs of both genders, various ages and weights, and different stages of MMVD (n=6 in B1 stage, n=6 in B2 stage, and n=8 in C stage), and 5 healthy CKCS which were included in the control group. Clinical, radiological, hematological, biochemical, echocardiographic, and electrocardiographic examinations were performed. The corrected QT interval duration in the MMVD group was longer than the control (p<0.05). However, there was no significant difference between B1, B2, and C. It was concluded that the corrected QT interval can give a significant distinction between healthy and MMVD CKCS dogs. |
| first_indexed | 2024-04-09T23:50:32Z |
| format | Article |
| id | doaj.art-9d1067f1ea0349939d95fd161614b65a |
| institution | Directory Open Access Journal |
| issn | 1409-7621 1857-7415 |
| language | English |
| last_indexed | 2024-04-09T23:50:32Z |
| publishDate | 2023-03-01 |
| publisher | Ss.Cyril and Methodius University, Skopje |
| record_format | Article |
| series | Macedonian Veterinary Review |
| spelling | doaj.art-9d1067f1ea0349939d95fd161614b65a2023-03-17T10:30:28ZengSs.Cyril and Methodius University, SkopjeMacedonian Veterinary Review1409-76211857-74152023-03-01461616710.2478/macvetrev-2023-0014Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve diseaseHande Sağoğlu0Remzi Gönül1Lora Koenhemsi2Emine Merve Alan3Suzan Murat4Ashkan Seddigh Nia5Mehmet Erman Or6Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeDepartment of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University - Cerrahpaşa, 34320 Istanbul, TürkiyeMyxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the formation of fatal arrhythmias such as torsades de pointes. A fast and accurate assessment is therefore essential. The study aimed to examine the changes in QT duration in MMVD cases of CKCS and to calculate the corrected QT durations with Bazett’s formula in various stages of the disease. The study included 20 CKCS dogs of both genders, various ages and weights, and different stages of MMVD (n=6 in B1 stage, n=6 in B2 stage, and n=8 in C stage), and 5 healthy CKCS which were included in the control group. Clinical, radiological, hematological, biochemical, echocardiographic, and electrocardiographic examinations were performed. The corrected QT interval duration in the MMVD group was longer than the control (p<0.05). However, there was no significant difference between B1, B2, and C. It was concluded that the corrected QT interval can give a significant distinction between healthy and MMVD CKCS dogs.https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2023_0014cavaliermyxomatousmitral valveqt |
| spellingShingle | Hande Sağoğlu Remzi Gönül Lora Koenhemsi Emine Merve Alan Suzan Murat Ashkan Seddigh Nia Mehmet Erman Or Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease Macedonian Veterinary Review cavalier myxomatous mitral valve qt |
| title | Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease |
| title_full | Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease |
| title_fullStr | Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease |
| title_full_unstemmed | Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease |
| title_short | Evaluation of the corrected QT interval with Bazett’s Method in Cavalier King Charles Spaniel dogs with myxomatous mitral valve disease |
| title_sort | evaluation of the corrected qt interval with bazett s method in cavalier king charles spaniel dogs with myxomatous mitral valve disease |
| topic | cavalier myxomatous mitral valve qt |
| url | https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2023_0014 |
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