Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies
Platelets are essential components in the tumor microenvironment. For decades, clinical data have demonstrated that cancer patients have a high risk of thrombosis that is associated with adverse prognosis and decreased survival, indicating the involvement of platelets in cancer progression. Increasi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.764119/full |
| _version_ | 1818587979380162560 |
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| author | Liuting Yu Yao Guo Zhiguang Chang Dengyang Zhang Shiqiang Zhang Hanzhong Pei Jun Pang Zhizhuang Joe Zhao Yun Chen |
| author_facet | Liuting Yu Yao Guo Zhiguang Chang Dengyang Zhang Shiqiang Zhang Hanzhong Pei Jun Pang Zhizhuang Joe Zhao Yun Chen |
| author_sort | Liuting Yu |
| collection | DOAJ |
| description | Platelets are essential components in the tumor microenvironment. For decades, clinical data have demonstrated that cancer patients have a high risk of thrombosis that is associated with adverse prognosis and decreased survival, indicating the involvement of platelets in cancer progression. Increasing evidence confirms that cancer cells are able to induce production and activation of platelets. Once activated, platelets serve as allies of cancer cells in tumor growth and metastasis. They can protect circulating tumor cells (CTCs) against the immune system and detachment-induced apoptosis while facilitating angiogenesis and tumor cell adhesion and invasion. Therefore, antiplatelet agents and platelet-based therapies should be developed for cancer treatment. Here, we discuss the mechanisms underlying the bidirectional cancer-platelet crosstalk and platelet-based therapeutic approaches. |
| first_indexed | 2024-12-16T09:17:28Z |
| format | Article |
| id | doaj.art-9d13b925000344dd9c8a4096d84e898d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T09:17:28Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9d13b925000344dd9c8a4096d84e898d2022-12-21T22:36:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-10-011110.3389/fonc.2021.764119764119Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer TherapiesLiuting Yu0Yao Guo1Zhiguang Chang2Dengyang Zhang3Shiqiang Zhang4Hanzhong Pei5Jun Pang6Zhizhuang Joe Zhao7Yun Chen8Edmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaEdmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaEdmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaEdmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaEdmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesEdmond H. Fischer Translational Medical Research Laboratory, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaPlatelets are essential components in the tumor microenvironment. For decades, clinical data have demonstrated that cancer patients have a high risk of thrombosis that is associated with adverse prognosis and decreased survival, indicating the involvement of platelets in cancer progression. Increasing evidence confirms that cancer cells are able to induce production and activation of platelets. Once activated, platelets serve as allies of cancer cells in tumor growth and metastasis. They can protect circulating tumor cells (CTCs) against the immune system and detachment-induced apoptosis while facilitating angiogenesis and tumor cell adhesion and invasion. Therefore, antiplatelet agents and platelet-based therapies should be developed for cancer treatment. Here, we discuss the mechanisms underlying the bidirectional cancer-platelet crosstalk and platelet-based therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fonc.2021.764119/fullplateletsthrombosiscancer cellscancer-platelet crosstalkcancer treatment |
| spellingShingle | Liuting Yu Yao Guo Zhiguang Chang Dengyang Zhang Shiqiang Zhang Hanzhong Pei Jun Pang Zhizhuang Joe Zhao Yun Chen Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies Frontiers in Oncology platelets thrombosis cancer cells cancer-platelet crosstalk cancer treatment |
| title | Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies |
| title_full | Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies |
| title_fullStr | Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies |
| title_full_unstemmed | Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies |
| title_short | Bidirectional Interaction Between Cancer Cells and Platelets Provides Potential Strategies for Cancer Therapies |
| title_sort | bidirectional interaction between cancer cells and platelets provides potential strategies for cancer therapies |
| topic | platelets thrombosis cancer cells cancer-platelet crosstalk cancer treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.764119/full |
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