Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation
Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as its effect of inducing radiation induced absco...
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| Format: | Article |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.597702/full |
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| author | Qingting Huang Qingting Huang Qingting Huang Yun Sun Yun Sun Weiwei Wang Weiwei Wang Lien-Chun Lin Lien-Chun Lin Yangle Huang Jing Yang Jing Yang Xiaodong Wu Xiaodong Wu Lin Kong Lin Kong Jiade Jay Lu Jiade Jay Lu |
| author_facet | Qingting Huang Qingting Huang Qingting Huang Yun Sun Yun Sun Weiwei Wang Weiwei Wang Lien-Chun Lin Lien-Chun Lin Yangle Huang Jing Yang Jing Yang Xiaodong Wu Xiaodong Wu Lin Kong Lin Kong Jiade Jay Lu Jiade Jay Lu |
| author_sort | Qingting Huang |
| collection | DOAJ |
| description | Recently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as its effect of inducing radiation induced abscopal effects (RIAEs) have not been well investigated. Herein, we developed a technique of carbon ion microporous radiation (CI-MPR), guided by 18F-FMISO PET/computerized tomography (CT), for partial volume radiation targeting the hypoxia area of a tumor and investigated its capability of inducing abscopal effects. Tumor-bearing mice were inoculated subcutaneously with breast cancer 4T1 cells into the flanks of both hind legs of mouse. Mice were assigned to three groups: group I: control group with no treatment; group II: carbon ion open field radiation (CI-OFR group) targeting the entire tumor; group III: partial volume carbon ion microporous radiation (CI-MPR group) targeting the hypoxia region. The tumors on the left hind legs of mice were irradiated with single fraction of 20 Gy of CIRT. Mice treated with CI-MPR or CI-OFR showed that significant growth delay on both the irradiated and unirradiated of tumor as compared to the control groups. Tumor regression of left tumor irradiated with CI-OFR was more prominent as compared to the tumor treated with CI-MPR, while the regression of the unirradiated tumor in both CI-MPR and CI-OFR group was similar. Biological-guided CIRT using the newly developed microporous technique targeting tumor hypoxia region could induce robust abscopal effects similar to CIRT covering the entire tumor. |
| first_indexed | 2024-12-14T17:18:13Z |
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| id | doaj.art-9d13bcb5de4d495e943c7c9b1996753a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T17:18:13Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9d13bcb5de4d495e943c7c9b1996753a2022-12-21T22:53:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.597702597702Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field RadiationQingting Huang0Qingting Huang1Qingting Huang2Yun Sun3Yun Sun4Weiwei Wang5Weiwei Wang6Lien-Chun Lin7Lien-Chun Lin8Yangle Huang9Jing Yang10Jing Yang11Xiaodong Wu12Xiaodong Wu13Lin Kong14Lin Kong15Jiade Jay Lu16Jiade Jay Lu17Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Research and Development, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaRecently, a growing number of studies focus on partial tumor irradiation to induce the stronger non-target effects. However, the value of partial volume carbon ion radiotherapy (CIRT) targeting hypoxic region of a tumor under imaging guidance as well as its effect of inducing radiation induced abscopal effects (RIAEs) have not been well investigated. Herein, we developed a technique of carbon ion microporous radiation (CI-MPR), guided by 18F-FMISO PET/computerized tomography (CT), for partial volume radiation targeting the hypoxia area of a tumor and investigated its capability of inducing abscopal effects. Tumor-bearing mice were inoculated subcutaneously with breast cancer 4T1 cells into the flanks of both hind legs of mouse. Mice were assigned to three groups: group I: control group with no treatment; group II: carbon ion open field radiation (CI-OFR group) targeting the entire tumor; group III: partial volume carbon ion microporous radiation (CI-MPR group) targeting the hypoxia region. The tumors on the left hind legs of mice were irradiated with single fraction of 20 Gy of CIRT. Mice treated with CI-MPR or CI-OFR showed that significant growth delay on both the irradiated and unirradiated of tumor as compared to the control groups. Tumor regression of left tumor irradiated with CI-OFR was more prominent as compared to the tumor treated with CI-MPR, while the regression of the unirradiated tumor in both CI-MPR and CI-OFR group was similar. Biological-guided CIRT using the newly developed microporous technique targeting tumor hypoxia region could induce robust abscopal effects similar to CIRT covering the entire tumor.https://www.frontiersin.org/articles/10.3389/fonc.2020.597702/fullcarbon ionmicroporous radiationhypoxia18F-FMISO PET/computerized tomographyabscopal effect |
| spellingShingle | Qingting Huang Qingting Huang Qingting Huang Yun Sun Yun Sun Weiwei Wang Weiwei Wang Lien-Chun Lin Lien-Chun Lin Yangle Huang Jing Yang Jing Yang Xiaodong Wu Xiaodong Wu Lin Kong Lin Kong Jiade Jay Lu Jiade Jay Lu Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation Frontiers in Oncology carbon ion microporous radiation hypoxia 18F-FMISO PET/computerized tomography abscopal effect |
| title | Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation |
| title_full | Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation |
| title_fullStr | Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation |
| title_full_unstemmed | Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation |
| title_short | Biological Guided Carbon-Ion Microporous Radiation to Tumor Hypoxia Area Triggers Robust Abscopal Effects as Open Field Radiation |
| title_sort | biological guided carbon ion microporous radiation to tumor hypoxia area triggers robust abscopal effects as open field radiation |
| topic | carbon ion microporous radiation hypoxia 18F-FMISO PET/computerized tomography abscopal effect |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.597702/full |
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