The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia
Infants and children with esophageal atresia commonly present with swallowing dysfunction or dysphagia. Dysphagia can lead to a range of significant consequences such as aspiration pneumonia, malnutrition, dehydration, and food impaction. To improve oral intake, the clinical diagnosis of dysphagia i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fped.2017.00137/full |
| _version_ | 1818928899377070080 |
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| author | Nathalie Rommel Nathalie Rommel Maissa Rayyan Maissa Rayyan Charlotte Scheerens Charlotte Scheerens Taher Omari |
| author_facet | Nathalie Rommel Nathalie Rommel Maissa Rayyan Maissa Rayyan Charlotte Scheerens Charlotte Scheerens Taher Omari |
| author_sort | Nathalie Rommel |
| collection | DOAJ |
| description | Infants and children with esophageal atresia commonly present with swallowing dysfunction or dysphagia. Dysphagia can lead to a range of significant consequences such as aspiration pneumonia, malnutrition, dehydration, and food impaction. To improve oral intake, the clinical diagnosis of dysphagia in patients with esophageal atresia should focus on both the pharynx and the esophagus. To characterize the complex interactions of bolus flow and motor function between mouth, pharynx, and esophagus, a detailed understanding of normal and abnormal deglutition is required through the use of adequate and objective assessment techniques. As clinical symptoms do not correlate well with conventional assessment methods of motor function such as radiology or manometry but do correlate with bolus flow, the current state-of-the-art diagnosis involves high-resolution manometry combined with impedance measurements to characterize the interplay between esophageal motor function and bolus clearance. Using a novel pressure flow analysis (PFA) method as an integrated analysis method of manometric and impedance measurements, differentiation of patients with impaired esophago-gastric junction relaxation from patients with bolus outflow disorders is clinically relevant. In this, pressure flow matrix categorizing the quantitative PFA measures may be used to make rational therapeutic decisions in patients with esophageal atresia. Through more advanced diagnostics, improved understanding of pathophysiology may improve our patient care by directly targeting the failed biomechanics of both the pharynx and the esophagus. |
| first_indexed | 2024-12-20T03:36:14Z |
| format | Article |
| id | doaj.art-9d171cf39f524816acdbaf4563b58fc8 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-20T03:36:14Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-9d171cf39f524816acdbaf4563b58fc82022-12-21T19:54:53ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602017-06-01510.3389/fped.2017.00137268493The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal AtresiaNathalie Rommel0Nathalie Rommel1Maissa Rayyan2Maissa Rayyan3Charlotte Scheerens4Charlotte Scheerens5Taher Omari6Neurogastroenterology and Motility, Gastroenterology, University Hospitals Leuven, Leuven, BelgiumExperimental Otorhinolaryngology, Department of Neurosciences, Deglutology, University of Leuven, Leuven, BelgiumNeonatal Intensive Care Unit, University Hospitals Leuven, Leuven, BelgiumDepartment of Development and Regeneration, University of Leuven, Leuven, BelgiumNeurogastroenterology and Motility, Gastroenterology, University Hospitals Leuven, Leuven, BelgiumExperimental Otorhinolaryngology, Department of Neurosciences, Deglutology, University of Leuven, Leuven, BelgiumSchool of Medicine, Flinders University, Adelaide, SA, AustraliaInfants and children with esophageal atresia commonly present with swallowing dysfunction or dysphagia. Dysphagia can lead to a range of significant consequences such as aspiration pneumonia, malnutrition, dehydration, and food impaction. To improve oral intake, the clinical diagnosis of dysphagia in patients with esophageal atresia should focus on both the pharynx and the esophagus. To characterize the complex interactions of bolus flow and motor function between mouth, pharynx, and esophagus, a detailed understanding of normal and abnormal deglutition is required through the use of adequate and objective assessment techniques. As clinical symptoms do not correlate well with conventional assessment methods of motor function such as radiology or manometry but do correlate with bolus flow, the current state-of-the-art diagnosis involves high-resolution manometry combined with impedance measurements to characterize the interplay between esophageal motor function and bolus clearance. Using a novel pressure flow analysis (PFA) method as an integrated analysis method of manometric and impedance measurements, differentiation of patients with impaired esophago-gastric junction relaxation from patients with bolus outflow disorders is clinically relevant. In this, pressure flow matrix categorizing the quantitative PFA measures may be used to make rational therapeutic decisions in patients with esophageal atresia. Through more advanced diagnostics, improved understanding of pathophysiology may improve our patient care by directly targeting the failed biomechanics of both the pharynx and the esophagus.http://journal.frontiersin.org/article/10.3389/fped.2017.00137/fullesophageal atresiadysphagiadysmotilityhigh-resolution manometrypressure flow analysis |
| spellingShingle | Nathalie Rommel Nathalie Rommel Maissa Rayyan Maissa Rayyan Charlotte Scheerens Charlotte Scheerens Taher Omari The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia Frontiers in Pediatrics esophageal atresia dysphagia dysmotility high-resolution manometry pressure flow analysis |
| title | The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia |
| title_full | The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia |
| title_fullStr | The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia |
| title_full_unstemmed | The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia |
| title_short | The Potential Benefits of Applying Recent Advances in Esophageal Motility Testing in Patients with Esophageal Atresia |
| title_sort | potential benefits of applying recent advances in esophageal motility testing in patients with esophageal atresia |
| topic | esophageal atresia dysphagia dysmotility high-resolution manometry pressure flow analysis |
| url | http://journal.frontiersin.org/article/10.3389/fped.2017.00137/full |
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