Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19
Introduction: Studies on nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels in COVID-19 patients are limited. This study aimed to investigate the relationship between some biomarkers of oxidant-antioxidant status with COVID-19 disease. Material and methods: The pa...
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| Format: | Article |
| Language: | English |
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Emergency Department of Hospital San Pedro (Logroño, Spain)
2023-10-01
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| Series: | Iberoamerican Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2024.0001 |
| _version_ | 1797353267281264640 |
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| author | Mehmet Çelik Mehmet Reşat Ceylan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan |
| author_facet | Mehmet Çelik Mehmet Reşat Ceylan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan |
| author_sort | Mehmet Çelik |
| collection | DOAJ |
| description | Introduction: Studies on nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels in COVID-19 patients are limited. This study aimed to investigate the relationship between some biomarkers of oxidant-antioxidant status with COVID-19 disease.
Material and methods: The patients older than 18 years of age who tested positive for SARS CoV-2 PCR (polymerase chain reaction) with clinical symptoms and signs were included in this study. Total antioxidant status (TAS), total antioxidant status (TOS), oxidative stress index (OSI) and HO-1 and Nrf2 levels were analyzed from serum samples taken before and after treatment.
Results: In this study, 16 patients followed up with the diagnosis of COVID-19 were included. 9 (56.3%) of the patients were female and 7 (43.8%) were male. The mean age was 33.75 ± 17.03 years. All patients were symptomatic and were hospitalized to be followed up. It was determined that Nrf2 and HO-1 values increased significantly after treatment. Moreover, there was a significant positive correlation between Nrf2 and TAS values and TAS increases significantly in parallel to an increase in Nrf2, and there was a significant but negative correlation between Nrf2 and TOS and OSI values, and thus an increase in Nrf2 led to a decrease in TOS and OSI values. There was a significant positive correlation between HO-1 and TAS, and TAS increased significantly, as HO-1 increased.
Conclusions: The decrease in TOS and OSI and the increase in Nrf2 and HO-1 during the follow-up period in COVID-19 patients suggest that the body tries to prevent ROS-related oxidative stress via Nrf2 and HO-1 and that oxidative stress may have a key role in the pathophysiology of COVID-19. |
| first_indexed | 2024-03-08T13:28:40Z |
| format | Article |
| id | doaj.art-9d172156db4644fe92f3cabe6856413e |
| institution | Directory Open Access Journal |
| issn | 2695-5075 |
| language | English |
| last_indexed | 2024-03-08T13:28:40Z |
| publishDate | 2023-10-01 |
| publisher | Emergency Department of Hospital San Pedro (Logroño, Spain) |
| record_format | Article |
| series | Iberoamerican Journal of Medicine |
| spelling | doaj.art-9d172156db4644fe92f3cabe6856413e2024-01-17T12:01:54ZengEmergency Department of Hospital San Pedro (Logroño, Spain)Iberoamerican Journal of Medicine2695-50752023-10-016139https://doi.org/10.53986/ibjm.2024.0001Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19Mehmet Çelik0https://orcid.org/0000-0002-0583-929XMehmet Reşat Ceylan1https://orcid.org/0000-0001-8063-4836 İsmail Koyuncu2https://orcid.org/0000-0002-8985-893XNevin Güler Dinçer3https://orcid.org/0000-0003-0361-1803Sevil Alkan4https://orcid.org/0000-0003-1944-2477University of Harran, Faculty of Medicine, Department of İnfectious Diseases and Clinical Microbiology, Şanlıurfa, TurkeyUniversity of Harran, Faculty of Medicine, Department of İnfectious Diseases and Clinical Microbiology, Şanlıurfa, Turkey University of Harran, Faculty of Medicine, Department of Medicinal Biochemistry, Şanlıurfa, Turkey University of Muğla Sıtkı Koçman, Faculty of Science, Department of Statistics, Muğla, Turkey Canakkale Onsekiz Mart University, Faculty of Medicine, Department of İnfectious Diseases and Clinical Microbiology, Canakkale, TurkeyIntroduction: Studies on nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels in COVID-19 patients are limited. This study aimed to investigate the relationship between some biomarkers of oxidant-antioxidant status with COVID-19 disease. Material and methods: The patients older than 18 years of age who tested positive for SARS CoV-2 PCR (polymerase chain reaction) with clinical symptoms and signs were included in this study. Total antioxidant status (TAS), total antioxidant status (TOS), oxidative stress index (OSI) and HO-1 and Nrf2 levels were analyzed from serum samples taken before and after treatment. Results: In this study, 16 patients followed up with the diagnosis of COVID-19 were included. 9 (56.3%) of the patients were female and 7 (43.8%) were male. The mean age was 33.75 ± 17.03 years. All patients were symptomatic and were hospitalized to be followed up. It was determined that Nrf2 and HO-1 values increased significantly after treatment. Moreover, there was a significant positive correlation between Nrf2 and TAS values and TAS increases significantly in parallel to an increase in Nrf2, and there was a significant but negative correlation between Nrf2 and TOS and OSI values, and thus an increase in Nrf2 led to a decrease in TOS and OSI values. There was a significant positive correlation between HO-1 and TAS, and TAS increased significantly, as HO-1 increased. Conclusions: The decrease in TOS and OSI and the increase in Nrf2 and HO-1 during the follow-up period in COVID-19 patients suggest that the body tries to prevent ROS-related oxidative stress via Nrf2 and HO-1 and that oxidative stress may have a key role in the pathophysiology of COVID-19.https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2024.0001heme oxygenase-1nuclear factor erythroid 2- related factor 2oxidative stress indextotal antioxidant statustotal oxidant status |
| spellingShingle | Mehmet Çelik Mehmet Reşat Ceylan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 Iberoamerican Journal of Medicine heme oxygenase-1 nuclear factor erythroid 2- related factor 2 oxidative stress index total antioxidant status total oxidant status |
| title | Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 |
| title_full | Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 |
| title_fullStr | Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 |
| title_full_unstemmed | Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 |
| title_short | Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 |
| title_sort | nuclear factor erythroid 2 related factor nrf2 heme oxygenase 1 ho 1 and total oxidant antioxidant status in patients with covid 19 |
| topic | heme oxygenase-1 nuclear factor erythroid 2- related factor 2 oxidative stress index total antioxidant status total oxidant status |
| url | https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2024.0001 |
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