Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats
The objective of this study was to investigate the defensive influence of methanol fraction and crude extract of cocoplum (Chrysobalanus icaco L.) on nickel toxicity in male Wistar rats. Biochemical analyses in the serum and tissues (liver and kidney) were carried out using standard procedures. Sig...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2024-01-01
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| Series: | Journal of Applied Sciences and Environmental Management |
| Subjects: | |
| Online Access: | https://www.ajol.info/index.php/jasem/article/view/263575 |
| _version_ | 1797243237582241792 |
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| author | O. Q. Stephen-Onojedje S. O. Asagba H. E. Kadiri |
| author_facet | O. Q. Stephen-Onojedje S. O. Asagba H. E. Kadiri |
| author_sort | O. Q. Stephen-Onojedje |
| collection | DOAJ |
| description |
The objective of this study was to investigate the defensive influence of methanol fraction and crude extract of cocoplum (Chrysobalanus icaco L.) on nickel toxicity in male Wistar rats. Biochemical analyses in the serum and tissues (liver and kidney) were carried out using standard procedures. Significant (p < 0.05) increase were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, fragmented deoxyribose nucleic acid (DNA), and decrease in albumin and total protein in serum and tissues of Group 2 when compared with Group 1. The oral administration of C. icaco methanol fraction and crude extract significantly decreased AST, ALT, ALP, creatinine, urea, fragmented DNA and increased albumin and total protein in the serum and tissues when compared with Group 2. The histology of various organs (liver and kidney) of Group 2 revealed inflammation of portal vein and degeneration of hepatocytes. The renal tubules showed inflammation of glomerulus and tubular cell. The administration of C. icaco extract markedly reduced the histological alterations of various organs studied. However, these efficacies were shown to be better in the methanol crude extract than the methanol fraction of C. icaco.
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| first_indexed | 2024-04-24T18:51:55Z |
| format | Article |
| id | doaj.art-9d1759aa87ab4d6eb707577d2ea94b89 |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T18:51:55Z |
| publishDate | 2024-01-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-9d1759aa87ab4d6eb707577d2ea94b892024-03-26T20:08:05ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992024-01-0128110.4314/jasem.v28i1.17Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar RatsO. Q. Stephen-OnojedjeS. O. AsagbaH. E. Kadiri The objective of this study was to investigate the defensive influence of methanol fraction and crude extract of cocoplum (Chrysobalanus icaco L.) on nickel toxicity in male Wistar rats. Biochemical analyses in the serum and tissues (liver and kidney) were carried out using standard procedures. Significant (p < 0.05) increase were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, fragmented deoxyribose nucleic acid (DNA), and decrease in albumin and total protein in serum and tissues of Group 2 when compared with Group 1. The oral administration of C. icaco methanol fraction and crude extract significantly decreased AST, ALT, ALP, creatinine, urea, fragmented DNA and increased albumin and total protein in the serum and tissues when compared with Group 2. The histology of various organs (liver and kidney) of Group 2 revealed inflammation of portal vein and degeneration of hepatocytes. The renal tubules showed inflammation of glomerulus and tubular cell. The administration of C. icaco extract markedly reduced the histological alterations of various organs studied. However, these efficacies were shown to be better in the methanol crude extract than the methanol fraction of C. icaco. https://www.ajol.info/index.php/jasem/article/view/263575Fractionation, Nickel toxicity, Heavy metals, cocoplum |
| spellingShingle | O. Q. Stephen-Onojedje S. O. Asagba H. E. Kadiri Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats Journal of Applied Sciences and Environmental Management Fractionation, Nickel toxicity, Heavy metals, cocoplum |
| title | Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats |
| title_full | Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats |
| title_fullStr | Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats |
| title_full_unstemmed | Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats |
| title_short | Defensive Influence of Methanol Fraction and Crude Extract of Cocoplum (Chrysobalanus icaco L.) on Nickel Toxicity in Male Wistar Rats |
| title_sort | defensive influence of methanol fraction and crude extract of cocoplum chrysobalanus icaco l on nickel toxicity in male wistar rats |
| topic | Fractionation, Nickel toxicity, Heavy metals, cocoplum |
| url | https://www.ajol.info/index.php/jasem/article/view/263575 |
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