Pathological Characteristic and Clinical Management of Pulmonary Carcinoid
Background and objective Treatment of pulmonary carcinoid is a comprehensive modality focusing on surgery. Thus, accurate and timely preoperative and intraoperative pathological diagnoses are very crucial. The aim of this study is to retrospectively analyze the pathological characteristics of pulmon...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2013-05-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.06 |
| _version_ | 1811263120000155648 |
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| author | Lei ZHU Yang SHEN-TU Jie ZHANG Xiaohong FAN |
| author_facet | Lei ZHU Yang SHEN-TU Jie ZHANG Xiaohong FAN |
| author_sort | Lei ZHU |
| collection | DOAJ |
| description | Background and objective Treatment of pulmonary carcinoid is a comprehensive modality focusing on surgery. Thus, accurate and timely preoperative and intraoperative pathological diagnoses are very crucial. The aim of this study is to retrospectively analyze the pathological characteristics of pulmonary carcinoid, its natural history, and patterns of disease progression to obtain evidence for clinical decision making. Methods Clinical and pathological data of 32 patients with pulmonary carcinoid were retrieved and retrospectively analyzed. The pathological characteristics and their relationship with clinical diagnosis and treatment effect were systematically studied. Results Among the 32 patients, 18 had typical carcinoid and 14 had atypical carcinoid. The male-to-female ratio was 2.2:1, and the average age was (44±15) years. Almost half of the patients were discovered by accident. The average maximum diameter was (3.1±1.3) cm. About 27 of all 32 cases (84.4%) were stage I, 2 were stage IIa, 2 were stage IIIa, and 1 was stage IV. The follow-up time was 5.2-9.7 years. The 5-year progression free survival of 15 typical carcinoid patients and 12 atypical carcinoid patients were 100% and 92.9%, respectively. The characteristic neuroendocrine morphology and variable expression levels of cytokeratin, chromogranin A, synaptophysin, CD56, and index of Ki-67 were important factors that differentiated pulmonary carcinoid from other tumors. Conclusion Pathological diagnosis of pulmonary carcinoid must combine morphology with immunohistochemistry. Early-stage patients can also achieve good effect after surgery. |
| first_indexed | 2024-04-12T19:38:58Z |
| format | Article |
| id | doaj.art-9d17ea821cc143b0932eec4010c41d55 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-12T19:38:58Z |
| publishDate | 2013-05-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-9d17ea821cc143b0932eec4010c41d552022-12-22T03:19:08ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872013-05-0116524625110.3779/j.issn.1009-3419.2013.05.06Pathological Characteristic and Clinical Management of Pulmonary CarcinoidLei ZHUYang SHEN-TUJie ZHANGXiaohong FANBackground and objective Treatment of pulmonary carcinoid is a comprehensive modality focusing on surgery. Thus, accurate and timely preoperative and intraoperative pathological diagnoses are very crucial. The aim of this study is to retrospectively analyze the pathological characteristics of pulmonary carcinoid, its natural history, and patterns of disease progression to obtain evidence for clinical decision making. Methods Clinical and pathological data of 32 patients with pulmonary carcinoid were retrieved and retrospectively analyzed. The pathological characteristics and their relationship with clinical diagnosis and treatment effect were systematically studied. Results Among the 32 patients, 18 had typical carcinoid and 14 had atypical carcinoid. The male-to-female ratio was 2.2:1, and the average age was (44±15) years. Almost half of the patients were discovered by accident. The average maximum diameter was (3.1±1.3) cm. About 27 of all 32 cases (84.4%) were stage I, 2 were stage IIa, 2 were stage IIIa, and 1 was stage IV. The follow-up time was 5.2-9.7 years. The 5-year progression free survival of 15 typical carcinoid patients and 12 atypical carcinoid patients were 100% and 92.9%, respectively. The characteristic neuroendocrine morphology and variable expression levels of cytokeratin, chromogranin A, synaptophysin, CD56, and index of Ki-67 were important factors that differentiated pulmonary carcinoid from other tumors. Conclusion Pathological diagnosis of pulmonary carcinoid must combine morphology with immunohistochemistry. Early-stage patients can also achieve good effect after surgery.http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.06Lung neoplasmsCarcinoidPathological characteristicClinical management |
| spellingShingle | Lei ZHU Yang SHEN-TU Jie ZHANG Xiaohong FAN Pathological Characteristic and Clinical Management of Pulmonary Carcinoid Chinese Journal of Lung Cancer Lung neoplasms Carcinoid Pathological characteristic Clinical management |
| title | Pathological Characteristic and Clinical Management of Pulmonary Carcinoid |
| title_full | Pathological Characteristic and Clinical Management of Pulmonary Carcinoid |
| title_fullStr | Pathological Characteristic and Clinical Management of Pulmonary Carcinoid |
| title_full_unstemmed | Pathological Characteristic and Clinical Management of Pulmonary Carcinoid |
| title_short | Pathological Characteristic and Clinical Management of Pulmonary Carcinoid |
| title_sort | pathological characteristic and clinical management of pulmonary carcinoid |
| topic | Lung neoplasms Carcinoid Pathological characteristic Clinical management |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.05.06 |
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