Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study
Background/Aims Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting glucose (FG) levels and cause-specific mortality rates in the general population. Methods A total of 326,547 Korean adults o...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2021-05-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-355.pdf |
| _version_ | 1819146055832305664 |
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| author | Yi-Suk Kim Yong-Moon Park Kyung-Do Han Jae-Seung Yun Yu-Bae Ahn Seung-Hyun Ko |
| author_facet | Yi-Suk Kim Yong-Moon Park Kyung-Do Han Jae-Seung Yun Yu-Bae Ahn Seung-Hyun Ko |
| author_sort | Yi-Suk Kim |
| collection | DOAJ |
| description | Background/Aims Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting glucose (FG) levels and cause-specific mortality rates in the general population. Methods A total of 326,547 Korean adults over 20 years of age, who had received a health checkup between 2006 and 2008 were selected from the Korean National Health Insurance Service sample cohort dataset and followed until 2015. We estimated hazard ratios (HRs) of all-cause mortality and cause-specific mortality relative to various range of FG levels. All causes of death were classified according to International Classification of Diseases (ICD)-10 codes. Results During follow-up (mean, 8.5 years), a total of 13,536 deaths (mortality rate 4.89/1,000 person-year) occurred; 4,916 deaths from cancer, 2,133 from cardiovascular disease, 762 from infectious disease, 199 from renal disease, and 5,526 from other causes. The overall mortality rate increased with an increase in FG category (HR, 1.78; 95% confidence interval, 1.65 to 1.92; in the ≥ 160 mg/dL). In addition, a J-shaped associations was found between FG levels and all-cause mortality after adjustment for age, sex, smoking, drinking, physical activity, body mass index, diabetes mellitus medication, hypertension, and dyslipidemia. In particular, the risk of cancer-mortality with high FG levels was increased for men but not women. Conclusions The risk of all-cause and cause-specific mortality showed the tendency to increase when the FG level was outside of the normal range, indicating a J-shaped relationship, in both men and women. |
| first_indexed | 2024-12-22T13:07:51Z |
| format | Article |
| id | doaj.art-9d18aa37db9947849b6117e1faf96684 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T13:07:51Z |
| publishDate | 2021-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-9d18aa37db9947849b6117e1faf966842022-12-21T18:24:49ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-05-0136364765810.3904/kjim.2019.355170420Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort studyYi-Suk Kim0Yong-Moon Park1Kyung-Do Han2Jae-Seung Yun3Yu-Bae Ahn4Seung-Hyun Ko5 Department of Anatomy Catholic Institute for Applied Anatomy, The Catholic University of Korea, Seoul, Korea Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting glucose (FG) levels and cause-specific mortality rates in the general population. Methods A total of 326,547 Korean adults over 20 years of age, who had received a health checkup between 2006 and 2008 were selected from the Korean National Health Insurance Service sample cohort dataset and followed until 2015. We estimated hazard ratios (HRs) of all-cause mortality and cause-specific mortality relative to various range of FG levels. All causes of death were classified according to International Classification of Diseases (ICD)-10 codes. Results During follow-up (mean, 8.5 years), a total of 13,536 deaths (mortality rate 4.89/1,000 person-year) occurred; 4,916 deaths from cancer, 2,133 from cardiovascular disease, 762 from infectious disease, 199 from renal disease, and 5,526 from other causes. The overall mortality rate increased with an increase in FG category (HR, 1.78; 95% confidence interval, 1.65 to 1.92; in the ≥ 160 mg/dL). In addition, a J-shaped associations was found between FG levels and all-cause mortality after adjustment for age, sex, smoking, drinking, physical activity, body mass index, diabetes mellitus medication, hypertension, and dyslipidemia. In particular, the risk of cancer-mortality with high FG levels was increased for men but not women. Conclusions The risk of all-cause and cause-specific mortality showed the tendency to increase when the FG level was outside of the normal range, indicating a J-shaped relationship, in both men and women.http://www.kjim.org/upload/pdf/kjim-2019-355.pdffastingblood glucosemortalitydiabetes mellituscohort study |
| spellingShingle | Yi-Suk Kim Yong-Moon Park Kyung-Do Han Jae-Seung Yun Yu-Bae Ahn Seung-Hyun Ko Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study The Korean Journal of Internal Medicine fasting blood glucose mortality diabetes mellitus cohort study |
| title | Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study |
| title_full | Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study |
| title_fullStr | Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study |
| title_full_unstemmed | Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study |
| title_short | Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study |
| title_sort | fasting glucose level and all cause or cause specific mortality in korean adults a nationwide cohort study |
| topic | fasting blood glucose mortality diabetes mellitus cohort study |
| url | http://www.kjim.org/upload/pdf/kjim-2019-355.pdf |
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