Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder
Disruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficit/hyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relations...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704667/?tool=EBI |
| _version_ | 1828097370099810304 |
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| author | Sanghyun Lee Soon-Beom Hong |
| author_facet | Sanghyun Lee Soon-Beom Hong |
| author_sort | Sanghyun Lee |
| collection | DOAJ |
| description | Disruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficit/hyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relationship between the two in the thalamus. We analyzed resting-state functional magnetic resonance imaging data obtained from the Addiction Connectome Preprocessed Initiative Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder database. Functional connectivity maps were extracted to compare thalamic connectivity among adults who had been diagnosed with attention-deficit/hyperactivity disorder during childhood according to whether or not they used cannabis. The study participants included 18 cannabis users and 15 cannabis non-users with childhood attention-deficit/hyperactivity disorder. Our results revealed that adults with attention-deficit/hyperactivity disorder who used cannabis (n = 18) had significantly decreased functional connectivity between the thalamus and parietal regions, which was particularly prominent in the inferior parietal areas, in comparison with those who did not use cannabis (n = 15). Left thalamic functional connectivity with the inferior parietal and middle frontal areas and right thalamic functional connectivity with the inferior parietal and superior frontal areas were increased in non-users of cannabis with attention-deficit/hyperactivity disorder compared with a local normative comparison group (n = 7). In conclusion, adults with a childhood history of attention-deficit/hyperactivity disorder who do not use cannabis often have relatively stronger thalamoparietal and thalamofrontal connectivity, which may help reduce the risk of cannabis use. |
| first_indexed | 2024-04-11T07:45:17Z |
| format | Article |
| id | doaj.art-9d1a6b140ca64f20a3a5262dc0264257 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T07:45:17Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9d1a6b140ca64f20a3a5262dc02642572022-12-22T04:36:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorderSanghyun LeeSoon-Beom HongDisruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficit/hyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relationship between the two in the thalamus. We analyzed resting-state functional magnetic resonance imaging data obtained from the Addiction Connectome Preprocessed Initiative Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder database. Functional connectivity maps were extracted to compare thalamic connectivity among adults who had been diagnosed with attention-deficit/hyperactivity disorder during childhood according to whether or not they used cannabis. The study participants included 18 cannabis users and 15 cannabis non-users with childhood attention-deficit/hyperactivity disorder. Our results revealed that adults with attention-deficit/hyperactivity disorder who used cannabis (n = 18) had significantly decreased functional connectivity between the thalamus and parietal regions, which was particularly prominent in the inferior parietal areas, in comparison with those who did not use cannabis (n = 15). Left thalamic functional connectivity with the inferior parietal and middle frontal areas and right thalamic functional connectivity with the inferior parietal and superior frontal areas were increased in non-users of cannabis with attention-deficit/hyperactivity disorder compared with a local normative comparison group (n = 7). In conclusion, adults with a childhood history of attention-deficit/hyperactivity disorder who do not use cannabis often have relatively stronger thalamoparietal and thalamofrontal connectivity, which may help reduce the risk of cannabis use.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704667/?tool=EBI |
| spellingShingle | Sanghyun Lee Soon-Beom Hong Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder PLoS ONE |
| title | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder |
| title_full | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder |
| title_fullStr | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder |
| title_full_unstemmed | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder |
| title_short | Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder |
| title_sort | thalamocortical functional connectivity and cannabis use in men with childhood attention deficit hyperactivity disorder |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704667/?tool=EBI |
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