EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES
The aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivatives in human primary cells and cell lines. Cytoki...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2011-04-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: | http://www.turkjps.org/archives/archive-detail/article-preview/effects-of-some-mchael-type-addton-products-on-var/12468 |
| _version_ | 1828018533624184832 |
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| author | Semra UTKU Mehtap GÖKÇE Erdem YEŞİLADA |
| author_facet | Semra UTKU Mehtap GÖKÇE Erdem YEŞİLADA |
| author_sort | Semra UTKU |
| collection | DOAJ |
| description | The aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivatives in human primary cells and cell lines. Cytokines are messengers for the regulation of the inflammatory cascades with Tumor Necrosis Factor-a (TNF-a), Interleukin (IL-lβ, IL-2, IL-4 andIL-8), Gamma Interferon (IFN-y) working synergistically. In this study which is performed in cell assay, inhibition capacity of compound 1, 2 and 3 derivatives againts TNF-a, IL-Iβ, IL-8, IL-2, IL-4 and IFN-y production by human whole blood have been measured. The test results were shown that 1, 2 and 3 derivatives have dose-dependent inhibitions on the release of IL-1β, IL-8 and TNF-a in lipopolysaccharide (LPS) stimulated human whole blood and IL-2, IL-4 and IFN-yin phorbolacetate (PHA) stimulated in human whole blood |
| first_indexed | 2024-04-10T11:05:49Z |
| format | Article |
| id | doaj.art-9d1b43a37a2948129cc2c17105093f17 |
| institution | Directory Open Access Journal |
| issn | 1304-530X 2146-6416 |
| language | English |
| last_indexed | 2024-04-10T11:05:49Z |
| publishDate | 2011-04-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-9d1b43a37a2948129cc2c17105093f172023-02-15T16:19:23ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi1304-530X2146-64162011-04-01815362EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINESSemra UTKU0Mehtap GÖKÇE1Erdem YEŞİLADA2Mersin University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, 33169 Mersin, TurkeyGazi University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, 06330 Ankara, TurkeyGazi University, Faculty Of Pharmacy, Department Of Pharmacognosy, 06330 Ankara, TurkeyThe aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivatives in human primary cells and cell lines. Cytokines are messengers for the regulation of the inflammatory cascades with Tumor Necrosis Factor-a (TNF-a), Interleukin (IL-lβ, IL-2, IL-4 andIL-8), Gamma Interferon (IFN-y) working synergistically. In this study which is performed in cell assay, inhibition capacity of compound 1, 2 and 3 derivatives againts TNF-a, IL-Iβ, IL-8, IL-2, IL-4 and IFN-y production by human whole blood have been measured. The test results were shown that 1, 2 and 3 derivatives have dose-dependent inhibitions on the release of IL-1β, IL-8 and TNF-a in lipopolysaccharide (LPS) stimulated human whole blood and IL-2, IL-4 and IFN-yin phorbolacetate (PHA) stimulated in human whole bloodhttp://www.turkjps.org/archives/archive-detail/article-preview/effects-of-some-mchael-type-addton-products-on-var/12468Anticytokine agentThiobenzoic acidThiomethylbenzimidazoleTNF-a |
| spellingShingle | Semra UTKU Mehtap GÖKÇE Erdem YEŞİLADA EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES Türk Yoğun Bakim Derneği Dergisi Anticytokine agent Thiobenzoic acid Thiomethylbenzimidazole TNF-a |
| title | EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES |
| title_full | EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES |
| title_fullStr | EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES |
| title_full_unstemmed | EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES |
| title_short | EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES |
| title_sort | effects of some michael type addition products on various cytokines |
| topic | Anticytokine agent Thiobenzoic acid Thiomethylbenzimidazole TNF-a |
| url | http://www.turkjps.org/archives/archive-detail/article-preview/effects-of-some-mchael-type-addton-products-on-var/12468 |
| work_keys_str_mv | AT semrautku effectsofsomemichaeltypeadditionproductsonvariouscytokines AT mehtapgokce effectsofsomemichaeltypeadditionproductsonvariouscytokines AT erdemyesilada effectsofsomemichaeltypeadditionproductsonvariouscytokines |