Probiotics in septic acute kidney injury, a double blind, randomized control trial
Introduction During acute kidney injury (AKI) due to sepsis, the intestinal microbiota changes to dysbiosis, which affects the kidney function recovery (KFR) and amplifies the injury. Therefore, the administration of probiotics could improve dysbiosis and thereby increase the probability of KFR.Meth...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2260003 |
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| author | Jonathan S. Chávez-Íñiguez Miguel Ibarra‑Estrada Alejandro Martínez Gallardo-González Ari Cisneros-Hernández Rolando Claure-Del Granado Gael Chávez-Alonso Eduardo M. Hernández-Barajas Alexia C. Romero-Muñoz Fidel Ramos-Avellaneda Manuel L. Prieto-Magallanes Marcela Plascencia-Cruz Jarumi A. Tanaka-Gutiérrez Cristina Pérez-Hernández Guillermo Navarro-Blackaller Ramón Medina-González Luz Alcantar-Vallin Karina Renoirte-López Guillermo García-García |
| author_facet | Jonathan S. Chávez-Íñiguez Miguel Ibarra‑Estrada Alejandro Martínez Gallardo-González Ari Cisneros-Hernández Rolando Claure-Del Granado Gael Chávez-Alonso Eduardo M. Hernández-Barajas Alexia C. Romero-Muñoz Fidel Ramos-Avellaneda Manuel L. Prieto-Magallanes Marcela Plascencia-Cruz Jarumi A. Tanaka-Gutiérrez Cristina Pérez-Hernández Guillermo Navarro-Blackaller Ramón Medina-González Luz Alcantar-Vallin Karina Renoirte-López Guillermo García-García |
| author_sort | Jonathan S. Chávez-Íñiguez |
| collection | DOAJ |
| description | Introduction During acute kidney injury (AKI) due to sepsis, the intestinal microbiota changes to dysbiosis, which affects the kidney function recovery (KFR) and amplifies the injury. Therefore, the administration of probiotics could improve dysbiosis and thereby increase the probability of KFR.Methods In this double-blind clinical trial, patients with AKI associated with sepsis were randomized (1:1) to receive probiotics or placebo for 7 consecutive days, with the objectives of evaluate the effect on KFR, mortality, kidney replacement therapy (KRT), urea, urine volume, serum electrolytes and adverse events at day 7.Results From February 2019 to March 2022, a total of 92 patients were randomized, 48 to the Probiotic and 44 to Placebo group. When comparing with placebo, those in the Probiotics did not observe a higher KFR (HR 0.93, 0.52–1.68, p = 0.81), nor was there a benefit in mortality at 6 months (95% CI 0.32–1.04, p = 0.06). With probiotics, urea values decreased significantly, an event not observed with placebo (from 154 to 80 mg/dl, p = 0.04 and from 130 to 109 mg/dl, p = 0.09, respectively). Urinary volume, need for KRT, electrolyte abnormalities, and adverse events were similar between groups. (ClinicalTrial.gov NCT03877081) (registered 03/15/2019).Conclusion In AKI related to sepsis, probiotics for 7 consecutive days did not increase the probability of KFR, nor did other variables related to clinical improvement, although they were safe. |
| first_indexed | 2024-03-11T23:45:10Z |
| format | Article |
| id | doaj.art-9d205cf1d1374820afb208c6494fd6de |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2025-03-21T19:37:45Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-9d205cf1d1374820afb208c6494fd6de2024-06-03T10:02:15ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2260003Probiotics in septic acute kidney injury, a double blind, randomized control trialJonathan S. Chávez-Íñiguez0Miguel Ibarra‑Estrada1Alejandro Martínez Gallardo-González2Ari Cisneros-Hernández3Rolando Claure-Del Granado4Gael Chávez-Alonso5Eduardo M. Hernández-Barajas6Alexia C. Romero-Muñoz7Fidel Ramos-Avellaneda8Manuel L. Prieto-Magallanes9Marcela Plascencia-Cruz10Jarumi A. Tanaka-Gutiérrez11Cristina Pérez-Hernández12Guillermo Navarro-Blackaller13Ramón Medina-González14Luz Alcantar-Vallin15Karina Renoirte-López16Guillermo García-García17Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoIntensive Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoDivision of Nutrition, NIN Institute, Guadalajara, Jalisco, MéxicoDivision of Nephrology, Hospital Obrero #2 – C.N.S, Universidad Mayor de San Simon School of Medicine, Cochabamba, BoliviaHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoNephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, MexicoHealth Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoIntroduction During acute kidney injury (AKI) due to sepsis, the intestinal microbiota changes to dysbiosis, which affects the kidney function recovery (KFR) and amplifies the injury. Therefore, the administration of probiotics could improve dysbiosis and thereby increase the probability of KFR.Methods In this double-blind clinical trial, patients with AKI associated with sepsis were randomized (1:1) to receive probiotics or placebo for 7 consecutive days, with the objectives of evaluate the effect on KFR, mortality, kidney replacement therapy (KRT), urea, urine volume, serum electrolytes and adverse events at day 7.Results From February 2019 to March 2022, a total of 92 patients were randomized, 48 to the Probiotic and 44 to Placebo group. When comparing with placebo, those in the Probiotics did not observe a higher KFR (HR 0.93, 0.52–1.68, p = 0.81), nor was there a benefit in mortality at 6 months (95% CI 0.32–1.04, p = 0.06). With probiotics, urea values decreased significantly, an event not observed with placebo (from 154 to 80 mg/dl, p = 0.04 and from 130 to 109 mg/dl, p = 0.09, respectively). Urinary volume, need for KRT, electrolyte abnormalities, and adverse events were similar between groups. (ClinicalTrial.gov NCT03877081) (registered 03/15/2019).Conclusion In AKI related to sepsis, probiotics for 7 consecutive days did not increase the probability of KFR, nor did other variables related to clinical improvement, although they were safe.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2260003AKIsepsisprobioticsintestinal dysbiosis |
| spellingShingle | Jonathan S. Chávez-Íñiguez Miguel Ibarra‑Estrada Alejandro Martínez Gallardo-González Ari Cisneros-Hernández Rolando Claure-Del Granado Gael Chávez-Alonso Eduardo M. Hernández-Barajas Alexia C. Romero-Muñoz Fidel Ramos-Avellaneda Manuel L. Prieto-Magallanes Marcela Plascencia-Cruz Jarumi A. Tanaka-Gutiérrez Cristina Pérez-Hernández Guillermo Navarro-Blackaller Ramón Medina-González Luz Alcantar-Vallin Karina Renoirte-López Guillermo García-García Probiotics in septic acute kidney injury, a double blind, randomized control trial Renal Failure AKI sepsis probiotics intestinal dysbiosis |
| title | Probiotics in septic acute kidney injury, a double blind, randomized control trial |
| title_full | Probiotics in septic acute kidney injury, a double blind, randomized control trial |
| title_fullStr | Probiotics in septic acute kidney injury, a double blind, randomized control trial |
| title_full_unstemmed | Probiotics in septic acute kidney injury, a double blind, randomized control trial |
| title_short | Probiotics in septic acute kidney injury, a double blind, randomized control trial |
| title_sort | probiotics in septic acute kidney injury a double blind randomized control trial |
| topic | AKI sepsis probiotics intestinal dysbiosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2260003 |
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