Pharmacophore Synergism in Diverse Scaffold Clinches in Aurora Kinase B
Aurora kinase B (AKB) is a crucial signaling kinase with an important role in cell division. Therefore, inhibition of AKB is an attractive approach to the treatment of cancer. In the present work, extensive quantitative structure–activity relationships (QSAR) analysis has been performed using a set...
Main Authors: | Vijay H. Masand, Sami A. Al-Hussain, Mithilesh M. Rathore, Sumer D. Thakur, Siddhartha Akasapu, Abdul Samad, Aamal A. Al-Mutairi, Magdi E. A. Zaki |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/23/14527 |
Similar Items
-
QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human <i>N</i>-Myristoyltransferase (Hs-NMT) Inhibitors
by: Magdi E. A. Zaki, et al.
Published: (2021-03-01) -
Mechanistic and Predictive QSAR Analysis of Diverse Molecules to Capture Salient and Hidden Pharmacophores for Anti-Thrombotic Activity
by: Magdi E. A. Zaki, et al.
Published: (2021-08-01) -
Mechanistic Analysis of Chemically Diverse Bromodomain-4 Inhibitors Using Balanced QSAR Analysis and Supported by X-ray Resolved Crystal Structures
by: Magdi E. A. Zaki, et al.
Published: (2022-06-01) -
Exploring the Prominent and Concealed Inhibitory Features for Cytoplasmic Isoforms of Hsp90 Using QSAR Analysis
by: Magdi E. A. Zaki, et al.
Published: (2022-03-01) -
Applications of the Novel Quantitative Pharmacophore Activity Relationship Method QPhAR in Virtual Screening and Lead-Optimisation
by: Stefan Michael Kohlbacher, et al.
Published: (2022-09-01)