Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody

Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody

ABSTRACTIMAB362/Zolbetuximab, a first-in-class IgG1 antibody directed against the cancer-associated gastric-lineage marker CLDN18.2, has recently been reported to have met its primary endpoint in two phase 3 trials as a first-line treatment in combination with standard of care chemotherapy in CLDN18...

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Main Authors: Hayat Bähr-Mahmud, Ursula Ellinghaus, Christiane R. Stadler, Leyla Fischer, Claudia Lindemann, Anuhar Chaturvedi, Jan Diekmann, Stefan Wöll, Imke Biermann, Bernhard Hebich, Caroline Scharf, Manuela Siefke, Alexandra S. Roth, Martin Rao, Kerstin Brettschneider, Eva-Maria Ewen, Uğur Şahin, Özlem Türeci
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
ADCC
BNT141
human CLDN18.2
IMAB362
immunotherapy
RiboMab
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2255041

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